Recovery of pituitary function after treatment with a targeted cytotoxic analog of luteinizing hormone-releasing hormone

Magdolna Kovacs; Andrew V. Schally; Attila Nagy

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Recovery of pituitary function after treatment with a targeted cytotoxic analog of luteinizing hormone-releasing hormone

机译：黄体生成素释放激素的靶向细胞毒性类似物治疗后垂体功能的恢复

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Recently, we developed a targeted cytotoxic analog AN-207 of luteinizing hormone-releasing hormone (LH-RH), consisting of an intensely potent derivative of doxorubicin, 2-pyrrolinodoxorubicin (AN-201) conjugated to carrier agonist [D-Lys]LH-RH. In this study, we investigated the effects of cytotoxic analog AN-207, designed for targeted chemotherapy and radical AN-201 on pituitary function in rats. A selective damage to the pituitary gonadotroph cells was found at 1 week after a single i.v. injection of 150 nmol/kg AN-207, as evidenced by a 63/100 decrease in the LH-RH- stimulated release of LH in vitro.

机译：最近，我们开发了一种促黄体生成激素释放激素（LH-RH）的靶向细胞毒类似物AN-207，其由与载体激动剂[D-Lys] LH缀合的阿霉素，2-吡咯啉/阿霉素（AN-201）的强效衍生物组成-RH。在这项研究中，我们调查了细胞毒性类似物AN-207（为靶向化疗而设计）和自由基AN-201对大鼠垂体功能的影响。一次静脉注射后1周发现对垂体促性腺激素细胞的选择性损伤。注射150 nmol / kg AN-207，如LH-RH刺激的体外LH释放降低63/100所证明。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第4期|p.1420-1425|共6页
作者
Magdolna Kovacs; Andrew V. Schally; Attila Nagy;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Targeted cytotoxic analogue of luteinizing hormone-releasing hormone (LH-RH) only transiently decreases the gene expression of pituitary receptors for LH-RH. [J] . Kovacs M, Schally AV, Csernus B, Journal of neuroendocrinology . 2002,第1期

机译：黄体生成激素释放激素（LH-RH）的靶向细胞毒类似物仅暂时降低LH-RH垂体受体的基因表达。
2. Experimental therapy of doxorubicin resistant human uveal melanoma with targeted cytotoxic luteinizing hormone-releasing hormone analog (AN-152) [J] . Gábor Oláh, Nikoletta Dobos, Gy?rgy Vámosi, European journal of pharmaceutical sciences . 2018,第期

机译：具有靶向细胞毒性酸型激素释放激素模拟（AN-152）的多柔比星抗性人体无过敏黑色素瘤的实验治疗
3. Targeted chemotherapy of endometrial, ovarian and breast cancers with cytotoxic analogs of luteinizing hormone-releasing hormone (LHRH) [J] . EngelJ.B., SchallyA.V., BuchholzS., Archives of gynecology and obstetrics. . 2012,第2期

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4. Synthesis and structural studies of new analogues of the decapeptide Luteinizing Hormone-Releasing Hormone (LHRH) [C] . Aikaterini A.Zompra, Dimitris Vachliotis, Georgios A.Spyroulias, European Peptide Symposium . 2002

机译：疏皮肽丁骨释放激素（LHRH）新型类似物的合成与结构研究
5. Luteinizing hormone-releasing hormone bound core-shell magnetite nanoparticles: Synthesis, characterization and studies of hyperthermia-induced cytotoxicity [D] . Mohammad, Faruq. 2011

机译：黄体生成激素释放激素结合的核壳磁铁矿纳米粒子：热疗诱导的细胞毒性的合成，表征和研究
6. Recovery of pituitary function after treatment with a targeted cytotoxic analog of luteinizing hormone-releasing hormone [O] . Magdolna Kovacs, Andrew V. Schally, Attila Nagy, 1997

机译：黄体化激素释放激素的靶向细胞毒类似物治疗后垂体功能的恢复
7. Regression of rat Dunning R-3327-H prostate carcinoma by treatment with targeted cytotoxic analog of luteinizing hormone-releasing hormone AN-207 containing 2-pyrrolinodoxorubicin [O] . Jungwirth, Andreas, Schally, Andrew V., Nagy, Attila, 2017

机译：用含有2-pyrrolinodoxorubicin的促黄体激素释放激素aN-207的靶向细胞毒性类似物治疗大鼠催眠R-3327-H前列腺癌的回归

Recovery of pituitary function after treatment with a targeted cytotoxic analog of luteinizing hormone-releasing hormone

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