Functional characterization of ETV6 and ETV6/CBFA2 in the regulation of the MCSFR proximal promoter

S. Fears; M. Gavin; D.-E. Zhang

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Functional characterization of ETV6 and ETV6/CBFA2 in the regulation of the MCSFR proximal promoter

机译：ETV6和ETV6 / CBFA2在MCSFR近端启动子调控中的功能表征

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The ETV6/CBFA2 (TEL/AML1) fusion gene occurs as a result of the chromosome translocation t(12;21)(p13;q22) in up to 30/100 of children diagnosed with B cell precursor (cd10+, cd19+) acute lymphoblastic leukemia. Leukemic cells that have acquired the t(12;21) usually dem- onstrate loss of the remaining normal ETV6 (TEL) allele. Using reporter gene assays we have functionally characterized both the normal ETV6 and ETV6/CBFA2 fusion proteins in the regulation of the MCSFR proximal promoter. Neither ETV6 or ETV6/CBFA2 has any significant, detectable effect on the promoter by itself.

机译：ETV6 / CBFA2（TEL / AML1）融合基因是染色体易位t（12; 21）（p13; q22）的结果，在多达30/100的被诊断患有B细胞前体（cd10 +，cd19 +）急性淋巴细胞的儿童中发生白血病。获得了t（12; 21）的白血病细胞通常可证明其余正常ETV6（TEL）等位基因的缺失。使用记者基因检测，我们已经在正常MCSFR近端启动子的调节中正常ETV6和ETV6 / CBFA2融合蛋白的功能表征。 ETV6或ETV6 / CBFA2本身对启动子都没有任何明显的可检测的作用。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第5期|p.1949-1954|共6页
作者
S. Fears; M. Gavin; D.-E. Zhang;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. FUNCTIONAL CHARACTERIZATION OF ETV6 AND ETV6/CBFA2 IN THE REGULATION OF THE MCSFR PROXIMAL PROMOTER [J] . Fears S., Zhang DE., Hetherington C., Proceedings of the National Academy of Sciences of the United States of America . 1997,第5期

机译：ETV6和ETV6 / CBFA2在MCSFR近端启动子调控中的功能表征
2. Functional characterization of a germline ETV6 variant associated with inherited thrombocytopenia, acute lymphoblastic leukemia, and salivary gland carcinoma in childhood [J] . International journal of hematology . 2020,第2期

机译：与遗传血小板减少症，急性淋巴细胞白血病和儿童唾液腺癌相关的种系ETV6变体功能表征
3. Comprehensive Functional Characterization of Germline ETV6 Variants Associated with Inherited Predisposition to Acute Lymphoblastic Leukemia in Children [J] . Nishii Rina, Baskin Rebekah, Moriyama Takaya, Blood: The Journal of the American Society of Hematology . 2016,第22期

机译：胚芽ETV6变异与遗传易感性与儿童急性淋巴细胞白血病相关的综合功能表征
4. Regulation of Genes Involved in Lipid Homeostasis and the Pathogenesis of Atherosclerosis: The Role of Promoters, Enhancers, Hormone Nuclear Receptors and Auxiliary Factors in Apolipoprotein Gene Regulation [C] . Vassilis Zannis, Eleoi Zanni, Dimitris Kardassis NATO Advanced Study Institute on Vascular Endothelium : Mechanisms of Cell Signaling . 1999

机译：调节患有脂质稳态的基因和动脉粥样硬化的发病机制：启动子，增强剂，激素核受体和载脂蛋白基因调控中的辅助因子的作用
5. Functional Evolution of Promoter-Proximal Pausing Factors in the Regulation of RNA Polymerase II Transcription [D] . Booth, Gregory T. 2018

机译：RNA聚合酶II转录调控中启动子 - 近端暂停因子的功能演变
6. Functional characterization of ETV6 and ETV6/CBFA2 in the regulation of the MCSFR proximal promoter [O] . S. Fears, M. Gavin, D.-E. Zhang, 1997

机译：ETV6和ETV6 / CBFA2在MCSFR近端启动子调控中的功能表征
7. Transcriptional regulation of the PXR gene: Identification and characterization of a functional peroxisome proliferator-activated receptor alpha binding site within the proximal promoter of PXR [O] . Aouabdi S, Gibson G, Plant N 2006

机译：PXR基因的转录调控：PXR近端启动子内功能性过氧化物酶体增殖物激活的受体α结合位点的鉴定和表征

Functional characterization of ETV6 and ETV6/CBFA2 in the regulation of the MCSFR proximal promoter

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