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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Incomplete endoplasmic reticulum (ER) retention in immature thymocytes as revealed by surface expression of 'ER-resident' molecular chaperones
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Incomplete endoplasmic reticulum (ER) retention in immature thymocytes as revealed by surface expression of 'ER-resident' molecular chaperones

机译：未成熟胸腺细胞内质网（ER）保留不完全，通过“ ER驻留”分子伴侣的表面表达揭示

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摘要

The folding and assembly of nascent proteins in the endoplasmic reticulum (ER) is assisted by molecular chaperones that are themselves retained within the ER. We now report that a number of different ER proteins, including molecular chaperones, are selectively expressed on the surface of immature thymocytes, but their surface expression is extinguished upon further differentiation. Escape from the ER is only possible for newly synthesized ER proteins before they become permanently retained. Thus, the cellular process of ER retention is incomplete in immature thymocytes and provides an explanation for surface expression of partial receptor complexes that transduce differentiative signals dur- ing thymic development.
机译：新生蛋白在内质网（ER）中的折叠和组装是由分子伴侣自身协助保留的。我们现在报告说，许多不同的ER蛋白，包括分子伴侣，选择性地表达在未成熟胸腺细胞的表面，但它们的表面表达在进一步分化后就消失了。只有在新合成的ER蛋白被永久保留之前，才有可能逃避ER。因此，ER保留的细胞过程在未成熟胸腺细胞中是不完全的，并为胸腺发育过程中转导分化信号的部分受体复合物的表面表达提供了解释。

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