GTP-bound forms of rab6 induce the redistribution of Golgi proteins into the endoplasmic reticulum

Olivier Martinez; Claude Antony; Gerard Pehau-Arnaudet

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GTP-bound forms of rab6 induce the redistribution of Golgi proteins into the endoplasmic reticulum

机译：GTP结合形式的rab6诱导高尔基体蛋白向内质网的重新分布

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摘要

rab6 is a ubiquitous ras-like GTPase in- volved in intra-Golgi transport. We have studied at both morphological and biochemical levels the behavior of Golgi resident proteins in HeLa cells overexpressing wild-type rab6 and GTP- and GDP-bound mutants of rab6 (rab6 Q72L and rab6 T27N, respectively). We show that wild-type rab6 and rab6 Q72L overexpression induces the redistribution of the trans-Golgi protein β-1,4-galactosyltransferase into the en- doplasmic reticulum (ER) and allows the addition of sialylated O-glycans on an ER-retained protein, the major histocompat- ibility complex class II-associated invariant chain.

机译：rab6是一种参与高尔基体内运输的普遍存在的ras样GTP酶。我们已经在形态和生化水平上研究了高表达野生型rab6和rab6的GTP结合和GDP结合的突变体（分别是rab6 Q72L和rab6 T27N）的HeLa细胞中高尔基驻留蛋白的行为。我们显示野生型rab6和rab6 Q72L过表达诱导反高尔基体蛋白β-1,4-半乳糖基转移酶重新分布到内质网（ER）中，并允许在ER保留的区域添加唾液酸化O-聚糖蛋白质，主要的组织相容性复合物II类相关不变链。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第5期|p.1828-1833|共6页
作者
Olivier Martinez; Claude Antony; Gerard Pehau-Arnaudet;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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专利

1. GTP-BOUND FORMS OF RAB6 INDUCE THE REDISTRIBUTION OF GOLGI PROTEINS INTO THE ENDOPLASMIC RETICULUM [J] . Martinez O., Pehauarnaudet G., Berger EG., Proceedings of the National Academy of Sciences of the United States of America . 1997,第5期

机译：GTP结合的RAB6形式促使高尔基蛋白重新分布到内质网
2. Mutations in the Drosophila ortholog of the vertebrate Golgi pH regulator (GPHR) protein disturb endoplasmic reticulum and Golgi organization and affect systemic growth Mutations in the Drosophila ortholog of the vertebrate Golgi pH regulator (GPHR) protein disturb endoplasmic reticulum and Golgi organization and affect systemic growth Mutations in the Drosophila ortholog of the vertebrate Golgi pH regulator (GPHR) protein disturb endoplasmic reticulum and Golgi organization and affect systemic growth [J] . Bernard Charroux, Julien Royet Biology Open . 2014,第1期

机译：果蝇直系同源物的脊椎动物高尔基体pH调节剂（GPHR）蛋白的突变扰乱内质网和高尔基体组织，影响全身生长果蝇直系同源物的脊椎动物高尔基体pH调节剂（GPHR）蛋白的突变体扰动内质网和高尔基体，影响全身生长果蝇直立同源的脊椎动物高尔基体pH调节剂（GPHR）蛋白的突变干扰内质网和高尔基体的组织，并影响系统性生长
3. TRIMERIC G PROTEINS REGULATE THE CYTOSOL-INDUCED REDISTRIBUTION OF GOLGI ENZYMES INTO THE ENDOPLASMIC RETICULUM [J] . Hidalgo J., Velasco A., Muniz M. Journal of Cell Science . 1995,第Pta4期

机译：三聚体G蛋白调节细胞溶胶诱导的高尔基酶向内质网的重新分布
4. The role of microtubules in transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells [C] . Krysten J.Palmer, Peter Watson, David J.Stephens Biochemical Society Symposium . 2005

机译：微管在哺乳动物细胞中的内质网和高压装置之间的运输中的作用
5. The association of calpain and its regulatory proteins with the endoplasmic reticulum and Golgi apparatus. [D] . Hood, Joshua L. 2004

机译：钙蛋白酶及其调节蛋白与内质网和高尔基体的联系。
6. GTP-bound forms of rab6 induce the redistribution of Golgi proteins into the endoplasmic reticulum [O] . Olivier Martinez, Claude Antony, Gérard Pehau-Arnaudet, 1997

机译：GTP结合形式的rab6诱导高尔基体蛋白重新分布到内质网中
7. Trimeric G proteins regulate the cytosol-induced redistribution of Golgi enzymes into the endoplasmic reticulum [O] . J. Hidalgo, M. Muniz, A. Velasco 1995

机译：三聚体G蛋白调节细胞质诱导的高尔基酶重新分布到内质网中

GTP-bound forms of rab6 induce the redistribution of Golgi proteins into the endoplasmic reticulum

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