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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Cytohesin-1, a cytosolic guanine nucleotide-exchange protein for ADP-ribosylation factor
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Cytohesin-1, a cytosolic guanine nucleotide-exchange protein for ADP-ribosylation factor

机译:Cytohesin-1,ADP-核糖基化因子的胞质鸟嘌呤核苷酸交换蛋白

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摘要

Cytohesin-1, a protein abundant in cells of the immune system, has been proposed to be a human homolog of the Saccharomyces cerevisiae Sec7 gene product, which is crucial in protein transport. More recently, the same protein has been reported to be a regulatory factor for the αLβ2 integrin in lymphocytes. Overexpression of human or yeast ADP-ribosylation factor (ARF) genes rescues yeast with Sec7 defects, restoring secretary pathway function.
机译:Cytohesin-1是一种在免疫系统细胞中富集的蛋白质,已被提出是酿酒酵母Sec7基因产物的人类同源物,它在蛋白质运输中至关重要。最近,据报道,相同的蛋白质是淋巴细胞中αLβ2整合素的调节因子。人或酵母ADP-核糖基化因子(ARF)基因的过表达可拯救具有Sec7缺陷的酵母,恢复秘书通路功能。

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