DEK, an autoantigen involved in a chromosomal translocation in acute myelogenous leukemia, binds to the HIV-2 enhancer

Glenn K. Fu; Gerard Grosveld; David M. Markovitz

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DEK, an autoantigen involved in a chromosomal translocation in acute myelogenous leukemia, binds to the HIV-2 enhancer

机译：DEK是一种参与急性骨髓性白血病中染色体易位的自身抗原，可与HIV-2增强剂结合

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The product of the dek oncogene is the 43- kDa DEK nuclear protein. DEK was first identified in a fusion with the CAN nucleoporin protein in a specific subtype of acute myelogenous leukemia. DEK has also been shown to be an autoantigen in patients with pauciarticular onset juvenile rheumatoid arthritis. Further, the last 65 amino acids of DEK can partially reverse the mutation-prone phenotype of cells from patients with ataxia-telangiectasia. However, in spite of these significant disease associations, the function of DEK has remained unclear.

机译：dek癌基因的产物是43kDa DEK核蛋白。首先在急性骨髓性白血病的特定亚型中，将DEK与CAN核孔蛋白融合在一起。 DEK还显示出在青春期关节炎类风湿关节炎患者中是一种自身抗原。此外，DEK的最后65个氨基酸可以部分逆转患有共济失调毛细血管扩张症患者的细胞的易突变表型。然而，尽管存在这些重要的疾病关联，但DEK的功能仍不清楚。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第5期|p.1811-1815|共5页
作者
Glenn K. Fu; Gerard Grosveld; David M. Markovitz;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. DEK, AN AUTOANTIGEN INVOLVED IN A CHROMOSOMAL TRANSLOCATION IN ACUTE MYELOGENOUS LEUKEMIA, BINDS TO THE HIV-2 ENHANCER [J] . Fu GK., Markovitz DM., Grosveld G. Proceedings of the National Academy of Sciences of the United States of America . 1997,第5期

机译：DEK是一种参与急性粒细胞白血病染色体易位的自身抗原，与HIV-2增强剂结合
2. NUP214-RAC1 and RAC1-COL12A1 Fusion in Complex Variant Translocations Involving Chromosomes 6, 7 and 9 in an Acute Myeloid Leukemia Case with DEK-NUP214 [J] . Abe Akihiro, Yamamoto Yukiya, Iba Sachiko, Cytogenetic and genome research . 2015,第4期

机译：NUP214-RAC1和RAC1-COL12A1在涉及DEK-NUP214的急性髓细胞白血病病例中涉及染色体6、7和9的复杂变异易位中融合。
3. A novel translocation t(3;21)(p21;q22) in acute myelogenous leukemia preceding a late-appearing Philadelphia chromosome [J] . A Quintás-Cardama, L V Abruzzo, F J Giles, Leukemia . 2006,第9期

机译：一种新型的易位t（3; 21）（p21; q22）在费城染色体出现之前的急性粒细胞性白血病中
4. Detecting different sub-types of acute myelogenous leukemia using dictionary learning and sparse representation [C] . Sarrafzadeh Omid, Rabbani Hossein, Dehnavi Alireza Mehri, IEEE International Conference on Image Processing . 2015

机译：使用字典学习和稀疏表示法检测急性骨髓性白血病的不同亚型
5. Chromosomal mapping of genes encoding human Pur-alpha and Pur-beta: Independent and simultaneous deletions in myelodysplastic syndromes and acute myelogenous leukemia. [D] . Lezon-Geyda, Kimberly Ann. 2001

机译：编码人Pur-alpha和Pur-beta的基因的染色体作图：骨髓增生异常综合症和急性骨髓性白血病的独立和同时缺失。
6. DEK an autoantigen involved in a chromosomal translocation in acute myelogenous leukemia binds to the HIV-2 enhancer [O] . Glenn K. Fu, Gerard Grosveld, David M. Markovitz 1997

机译：DEK是一种参与急性骨髓性白血病中染色体易位的自身抗原可与HIV-2增强子结合
7. A novel translocation t(3;21)(p21;q22) in acute myelogenous leukemia preceding a late-appearing Philadelphia chromosome [O] . A Quintás-Cardama, L V Abruzzo, F J Giles, 2006

机译：在出现后期费城染色体之前的急性髓性白血病中的新型易位T（3; 21）（P21; Q22）
8. Quantitative Risk Assessment of Exposures to Butadiene in European Union Occupational Settings Based on the University of Alabama at Birmingham Epidemiology Study: Acute Myelogenous Leukemia, Chronic Lymphocytic Leukemia, and Chronic Myelogenous Leukemia [R] . Silken, R. L., Valdez-Flores, C. 2007

机译：基于阿拉巴马大学伯明翰分校的流行病学研究：急性髓性白血病，慢性淋巴细胞白血病和慢性粒细胞白血病，欧盟职业环境中丁二烯暴露的定量风险评估

DEK, an autoantigen involved in a chromosomal translocation in acute myelogenous leukemia, binds to the HIV-2 enhancer

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