Daidzin inhibits mitochondrial aldehyde dehydrogenase and suppresses ethanol intake of Syrian golden hamsters

Wing Ming Keung; Anatole A. Klyosov; Bert L. Vallee

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Daidzin inhibits mitochondrial aldehyde dehydrogenase and suppresses ethanol intake of Syrian golden hamsters

机译：大豆苷抑制线粒体醛脱氢酶并抑制叙利亚金仓鼠的乙醇摄入

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Daidzin is the major active principle in ex- tracts of radix puerariae, a traditional Chinese medication that suppresses the ethanol intake of Syrian golden hamsters. It is the first isoflavone recognized to have this effect. Daidzin is also a potent and selective inhibitor of human mitochondrial aldehyde dehydrogenase (ALDH-2). To establish a link be- tween these two activities, we have tested a series of synthetic structural analogs of daidzin. The results demonstrate a direct correlation between ALDH-2 inhibition and ethanol intake suppression and raise the possibility that daidzin may, in fact, suppress ethanol intake of golden hamsters by inhib- iting ALDH-2.

机译：大豆苷是葛根提取物中的主要活性成分，葛根是抑制叙利亚金仓鼠摄入乙醇的传统中药。这是第一个被认为具有这种作用的异黄酮。大豆苷也是人线粒体醛脱氢酶（ALDH-2）的有效和选择性抑制剂。为了建立这两个活动之间的联系，我们测试了大豆苷的一系列合成结构类似物。结果表明，ALDH-2抑制与乙醇摄入抑制之间存在直接相关性，并增加了大豆黄酮实际上可以通过抑制ALDH-2抑制金黄仓鼠的乙醇摄入。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第5期|p.1675-1679|共5页
作者
Wing Ming Keung; Anatole A. Klyosov; Bert L. Vallee;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. DAIDZIN INHIBITS MITOCHONDRIAL ALDEHYDE DEHYDROGENASE AND SUPPRESSES ETHANOL INTAKE OF SYRIAN GOLDEN HAMSTERS [J] . Keung WM., Vallee BL., Klyosov AA. Proceedings of the National Academy of Sciences of the United States of America . 1997,第5期

机译：大黄素抑制线粒体醛脱氢酶并抑制叙利亚金黄仓鼠的乙醇摄入
2. DAIDZIN SUPPRESSES ETHANOL CONSUMPTION BY SYRIAN GOLDEN HAMSTERS WITHOUT BLOCKING ACETALDEHYDE METABOLISM [J] . Keung WM., Kunze L., Vallee BL., Proceedings of the National Academy of Sciences of the United States of America . 1995,第19期

机译：大黄素抑制了没有阻滞乙醛代谢的叙利亚金黄仓鼠的乙醇消耗
3. Activation of mitochondrial aldehyde dehydrogenase (ALDH2) by ALDA-1 reduces both the acquisition and maintenance of ethanol intake in rats: A dual mechanism? [J] . Rivera-Meza Mario, Vasquez David, Elena Quintanilla Maria, Neuropharmacology . 2019,第期

机译：通过ALDA-1活化线粒体醛脱氢酶（ALDH2）降低了大鼠乙醇摄入的获取和维持：双重机制？
4. Distribution and photodynamic effect of meta-tetrahydroxyphenylchlorin (mTHPC) in the pancreas and adjacent tissues in Syrian golden hamsters [C] . Peter Mlkvy, National Cancer Ctr., London, 5th International Photodynamic Association Biennial Meeting . 1995

机译：叙利亚金仓鼠胰腺及邻近组织中间四羟基苯氯菊酯（mTHPC）的分布和光动力效应
5. Comparative Host Response and Gene Regulation in Deer Mice and Syrian Golden Hamsters During Acute Infection with Modoc Virus [D] . Sherman, Tyler. 2020

机译：Modoc病毒急性感染鹿小鼠和叙利亚金仓鼠的比较宿主反应和基因调节
6. Daidzin inhibits mitochondrial aldehyde dehydrogenase and suppresses ethanol intake of Syrian golden hamsters [O] . Wing Ming Keung, Anatole A. Klyosov, Bert L. Vallee 1997

机译：大豆苷抑制线粒体醛脱氢酶并抑制叙利亚金仓鼠的乙醇摄入
7. Daidzin suppresses ethanol consumption by Syrian golden hamsters without blocking acetaldehyde metabolism. [O] . Keung, W M, Lazo, O, Kunze, L, 1995

机译：大豆苷抑制叙利亚金仓鼠消耗乙醇，而不会阻止乙醛代谢。
8. Methods and Compositions for Modulating Mitochondrial Aldehyde Dehydrogenase-2. [R] . Mochly-Rosen, D., Chen, C. H. 2004

机译：用于调节线粒体醛脱氢酶-2的方法和组合物。

Daidzin inhibits mitochondrial aldehyde dehydrogenase and suppresses ethanol intake of Syrian golden hamsters

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