Pore size of the malaria parasite's nutrient channel

Sanjay A. Desai; Robert L. Rosenberg

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Pore size of the malaria parasite's nutrient channel

机译：疟原虫营养通道的孔径

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The malaria parasite, Plasmodium falcipa- rum, requires large amounts of nutrients to sustain its rapid growth within the human red blood cell. A recently identified ion channel on the surface of the intraerythrocytic parasite may provide direct access to these nutrients in the red blood cell cytosol. Evidence supporting this role was obtained by incorporating this channel into planar lipid bilayers. In bilayers, this channel has conductance and gating properties identical to the in situ channel, passes soluble macromolecules of up to 1400 Da, and functions as a high capacity, low affinity molecular sieve.

机译：疟原虫恶性疟原虫需要大量营养以维持其在人红细胞中的快速生长。红细胞内寄生虫表面上最近发现的离子通道可以直接进入红细胞细胞质中的这些养分。通过将此通道整合到平面脂质双层中获得了支持该作用的证据。在双层中，此通道具有与原位通道相同的电导和门控特性，可通过高达1400 Da的可溶性大分子，并具有高容量，低亲和力的分子筛功能。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第5期|p.2045-2049|共5页
作者
Sanjay A. Desai; Robert L. Rosenberg;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. PORE SIZE OF THE MALARIA PARASITES NUTRIENT CHANNEL [J] . Desai SA., Rosenberg RL. Proceedings of the National Academy of Sciences of the United States of America . 1997,第5期

机译：疟疾寄生虫营养通道的孔径
2. CLAG3 Self-Associates in Malaria Parasites and Quantitatively Determines Nutrient Uptake Channels at the Host Membrane [J] . Ankit Gupta, Praveen Balabaskaran-Nina, Wang Nguitragool, MBio . 2018,第3期

机译：CLAG3自相关的疟疾寄生虫，并定量确定宿主膜的营养吸收通道。
3. Solute restriction reveals an essential role for clag3-associated channels in malaria parasite nutrient acquisition [J] . Molecular pharmacology. . 2012,第6期

机译：溶质的限制揭示了与疟疾寄生虫养分获取中的clag3相关通道的重要作用
4. IONIC TRANSPORT IN FINITE LENGTH NANO-SIZED PORES AND CHANNELS [C] . S. W. Hung, C. P. Chen, C. C. Chieng Micro/Nanoscale Heat Transfer International Conference 2008 . 2008

机译：有限长度纳米孔和通道的离子传输
5. Malaria and helminth co-infection: Investigations into malaria pathogenesis, immunology, parasite transmission, and vaccine response. [D] . Noland, Gregory S. 2007

机译：疟疾和蠕虫共感染：疟疾发病机理，免疫学，寄生虫传播和疫苗反应的调查。
6. Pore size of the malaria parasite’s nutrient channel [O] . Sanjay A. Desai, Robert L. Rosenberg 1997

机译：疟原虫的营养通道的孔径
7. Erratum for Gupta et al., “CLAG3 Self-Associates in Malaria Parasites and Quantitatively Determines Nutrient Uptake Channels at the Host Membrane” [O] . Ankit Gupta, Praveen Balabaskaran-Nina, Wang Nguitragool, 2018

机译：Gupta等人的错误，“Clag3在疟疾寄生虫中的自我联系，并定量地确定了主膜的营养吸收通道”
8. Nutrient (Lipid, Nucleoside, and Soluble Metabolite) Studies on Intraerythrocytic Malaria Parasites [R] . Tiner, J. D. 1972

机译：营养素（脂质，核苷和可溶性代谢物）对红细胞内疟疾寄生虫的研究

Pore size of the malaria parasite's nutrient channel

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