The antigen-binding domain of a human IgG-anti- F(ab')_2 autoantibody

Martin Welschof; Peter Terness; Sergey M. Kipriyanov

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The antigen-binding domain of a human IgG-anti- F(ab')_2 autoantibody

机译：人IgG-抗F（ab'）_ 2自身抗体的抗原结合结构域

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Recent studies revealed an immunoregula- tory role of natural IgG-anti-F(ab')_2 antibodies in both healthy individuals and patients with certain diseases. The implication of anti-F(ab')_2 antibodies in the pathogenesis of diseases prompted us to study the gene segment structure of their antigen-binding domains and their binding character- istics. cDNA was prepared from the lymphocytes of a patient with a high IgG-anti-F(ab')_2 serum titer. Variable heavy and light gene segments were amplified by PCR and inserted into a phagemid surface expression vector.

机译：最近的研究揭示了天然IgG-抗F（ab'）_ 2抗体在健康个体和某些疾病患者中的免疫调节作用。抗F（ab'）_ 2抗体在疾病的发病机理中的意义促使我们研究其抗原结合结构域的基因片段结构及其结合特性。从具有高IgG-抗-F（ab'）_ 2血清滴度的患者的淋巴细胞中制备cDNA。通过PCR扩增可变的重和轻基因片段，并将其插入噬菌粒表面表达载体。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第5期|p.1902-1907|共6页
作者
Martin Welschof; Peter Terness; Sergey M. Kipriyanov;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. THE ANTIGEN-BINDING DOMAIN OF A HUMAN IGG-ANTI-F(AB')(2) AUTOANTIBODY [J] . Welschof M., Kipriyanov SM., Stanescu D., Proceedings of the National Academy of Sciences of the United States of America . 1997,第5期

机译：人类IGG-ANTI-F（AB'）（2）自体抗体的抗原结合域
2. Antigen-binding affinity and thermostability of chimeric mouse-chicken IgY and mouse-human IgG antibodies with identical variable domains [J] . Juho Choi, Minjae Kim, Joungmin Lee, Scientific reports. . 2019,第1期

机译：嵌合小鼠鸡IgY和小鼠 - 人IgG抗体的抗原结合亲和力和热稳定性，具有相同可变域的抗体
3. Top-down Mass Spectrometry Analysis of Human Serum Autoantibody Antigen-Binding Fragments [J] . Zhe Wang, Xiaowen Liu, Jennifer Muther, Scientific reports. . 2019,第1期

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6. The antigen-binding domain of a human IgG-anti-F(ab′)2 autoantibody [O] . Martin Welschof, Peter Terness, Sergey M. Kipriyanov, 1997

机译：人IgG-抗F（ab）2自身抗体的抗原结合结构域
7. The antigen-binding domain of a human IgG-anti-F(ab')2 autoantibody [O] . M. Welschof, P. Terness, S. M. Kipriyanov, 1997

机译：人IgG-ant-F（AB'）2的抗原结合结构域2Aualantibody

The antigen-binding domain of a human IgG-anti- F(ab')_2 autoantibody

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