FROM PHOSPHATASES TO VANADIUM PEROXIDASES - A SIMILAR ARCHITECTURE OF THE ACTIVE SITE

Hemrika W.; Dekker HL.; Barnett P.; Wever R.; Renirie R.

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FROM PHOSPHATASES TO VANADIUM PEROXIDASES - A SIMILAR ARCHITECTURE OF THE ACTIVE SITE

机译：从磷酸酶到钒过氧化物酶-活性位点的相似结构

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We show here that the amino acid residues contributing to the active sites of the vanadate containing haloperoxidases are conserved within three families of acid phosphatases; this suggests that the active sites of these enzymes are very similar, This is confirmed by activity measurements showing that apochloroperoxidase exhibits phosphatase activity, These observations not only reveal interesting evolutionary relationships between these groups of enzymes but may also have important implications for the research on acid phosphatases, especially glucose-6-phosphatase-the enzyme affected in von Gierke disease-of which the predicted membrane topology may have to be reconsidered. [References: 37]

机译：我们在这里表明，贡献于含有卤化过氧化物的钒酸盐的活性位点的氨基酸残基在酸性磷酸酶的三个家族中是保守的。这表明这些酶的活性位点非常相似，这通过活性测量证实，载脂蛋白过氧化物酶具有磷酸酶活性。这些观察结果不仅揭示了这些酶之间有趣的进化关系，而且可能对酸的研究具有重要意义。磷酸酶，尤其是葡萄糖6磷酸酶-冯·吉尔克病中受影响的酶-必须重新考虑其预测的膜拓扑。 [参考：37]

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来源
《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第6期|p. 2145-2149|共5页
作者
Hemrika W.; Dekker HL.; Barnett P.; Wever R.; Renirie R.;
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作者单位

UNIV AMSTERDAM EC SLATER INST BIOCHEM RES PLANTAGE MUIDERGRACHT 12 NL-1018 TV AMSTERDAM NETHERLANDS;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Vanadate; Haloperoxidase; Glucose-6-phosphatase; Acid phosphatases; Fungus curvularia-inaequalis; Prostatic acid-phosphatase; Storage-disease type-1a; Ascophyllum-nodosum; Substrate-specificity; Directed mutagenesis; Enzyme-deficient; Chloroperoxidase; Glucose-6-phosphatase; Bromoperoxidase;

机译：钒酸盐;过氧化物酶;葡萄糖-6-磷酸酶;酸性磷酸酶;弯曲弯曲菌;前列腺酸性磷酸酶;存储疾病-1a型;棘孢菌;底物特异性;定向诱变;酶缺陷;氯过氧化物酶;葡萄糖-6 -磷酸酶;溴过氧化物酶;

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1. From phosphatases to vanadium peroxidases: A similar architecture of the active site [J] . Wieger Hemrika, Rokus Renirie, Henk L. Dekker Proceedings of the National Academy of Sciences of the United States of America . 1997,第6期

机译：从磷酸酶到钒过氧化物酶：活性位点的相似结构
2. Crystal Structure Analysis of Cationic Peroxidase from Proso Millet and Identification of Its Phosphatase Active Sites [J] . Cui Xiaodong, Wang Ke, Wang Tingfen, Journal of Agricultural and Food Chemistry . 2021,第22期

机译：来自Proso Millet的阳离子过氧化物酶的晶体结构分析及其磷酸酶活性位点的鉴定
3. Modeling the active site structures of vanadate-dependent peroxidases and vanadate-inhibited phosphatases [J] . Dieter Rehder, Martin Ebel, Cornelia Wikete, Pure and Applied Chemistry . 2005,第9期

机译：模拟钒酸盐依赖性过氧化物酶和钒酸盐抑制的磷酸酶的活性位点结构
4. Characterization of Novel Oxidation Products of Cysteine in Synthetic Active Site motif HCSAGIGRS of Protein Tyrosine Phosphatase 1B [C] . Vivekananda Shetty, Thomas A Neubert ASMS Conference on Mass Spectrometry and Allied Topics . 2008

机译：蛋白质酪氨酸磷酸酶1B蛋白酪氨酸磷酸酶1B中半胱氨酸新型氧化产物的表征
5. Part I. Magnetic circular dichroism studies of cytochrome c peroxidase from yeast: Investigations of the active site heme coordination sphere through comparison with horseradish peroxidase and myoglobin. Part II. Examination of the heme active site coordination structure of the cavity mutants of myoglobin (H93G), cytochrome c peroxidase (H175G), and heme oxygenase (H25A) and structural investigation of thiolate-ligated cytochrome c peroxidase in the H17C/D235L double mutant. [D] . Pond, Alycen Easterling. 1999

机译：第一部分。酵母中细胞色素C过氧化物酶的磁性圆二色性研究：通过与辣根过氧化物酶和肌红蛋白的比较，研究了活性部位血红素配位域。第二部分检查肌红蛋白（H93G），细胞色素c过氧化物酶（H175G）和血红素加氧酶（H25A）的空腔突变体的血红素活性位点配位结构，以及H17C / D235L双突变体中硫醇盐连接的细胞色素c过氧化物酶的结构研究。
6. From phosphatases to vanadium peroxidases: A similar architecture of the active site [O] . Wieger Hemrika, Rokus Renirie, Henk L. Dekker, 1997

机译：从磷酸酶到钒过氧化物酶：活性位的相似结构
7. From phosphatases to vanadium peroxidases: a similar architecture of the active site [O] . Hemrika, W., Renirie, R., Dekker, H. L., 1997

机译：从磷酸酶到钒过氧化物酶：活性位点的相似结构
8. Energetics of Cation Radical Formation at the Proximal Active Site Tryptophan of Cytochrome-c-Peroxidase and Ascorbate Peroxidase [R] . Jensen, G. M. , Bunte, S. W. , Warshel, A. , 1998

机译：细胞色素-c-过氧化物酶和抗坏血酸过氧化物酶的近端活性位点色氨酸阳离子形成的能量学

FROM PHOSPHATASES TO VANADIUM PEROXIDASES - A SIMILAR ARCHITECTURE OF THE ACTIVE SITE

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