SUPERCOIL-INDUCED EXTRUSION OF A REGULATORY DNA HAIRPIN

Dai X.; Nadaschinni K.; Rothmandenes LB.; Greizerstein MB.

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SUPERCOIL-INDUCED EXTRUSION OF A REGULATORY DNA HAIRPIN

机译：超螺旋诱导的调控DNA发夹的挤出

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Bacteriophage N4 virion RNA polymerase (N4 vRNAP) promoters contain inverted repeats, which form a 5- to 7-base-pair stem, 3-base loop hairpin that is required for vRNAP recognition, We show that, contrary to certain theoretical predictions, hairpin extrusion can occur at physiological superhelical densities in a Mg2+-dependent manner, Specific sequences on the template strand are required for hairpin extrusion, These sequences define stable DNA hairpins that are relatively unreactive to single strand-specific probes, In addition, a specific stable hairpin-inducing sequence can regulate transcription in vivo, Thus, a DNA structure, in its natural environment, is involved in transcriptional regulation. [References: 45]

机译：噬菌体N4病毒体RNA聚合酶（N4 vRNAP）启动子包含反向重复序列，形成vRNAP识别所需的5至7个碱基对的茎，3个碱基的环发夹。我们证明，与某些理论预测相反，发夹可以Mg2 +依赖的方式在生理超螺旋密度下发生挤压，发夹挤压需要模板链上的特定序列。这些序列定义了稳定的DNA发夹，与单链特异性探针相对没有反应。 -诱导序列可以在体内调节转录，因此，DNA结构在其天然环境中参与转录调节。 [参考：45]

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第6期|p. 2174-2179|共6页
作者
Dai X.; Nadaschinni K.; Rothmandenes LB.; Greizerstein MB.;
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作者单位

UNIV CHICAGO DEPT MOL GENET & CELL BIOL 920 E 58TH ST CHICAGO IL 60637 USA;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词
Virion rna-polymerase; Escherichia-coli; Stranded dna; Transcriptional activator; Gene-expression; Binding protein; Late promoters; Cruciform; Initiation; )atp/)adp;

机译：病毒RNA聚合酶;大肠杆菌;链DNA;转录激活子;基因表达;结合蛋白;晚期启动子;十字形;启动;）atp /）adp;

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专利

1. Supercoil-induced extrusion of a regulatory DNA hairpin [J] . Xing Dai, Miriam B. Greizerstein, Krisztina Nadas-Chinni Proceedings of the National Academy of Sciences of the United States of America . 1997,第6期

机译：超螺旋诱导的调控DNA发夹的挤出
2. Sequence-dependent extrusion of a small DNA hairpin at the n4 virion RNA polymerase promoters [J] . Dai X., Rothman-Denes LB., Kloster M. Journal of Molecular Biology . 1998,第1期

机译：小分子DNA发夹在n4病毒体RNA聚合酶启动子上的序列依赖性挤出
3. LIGAND BINDING ISOTHERM FOR DNA IN THE PRESENCE OF SUPERCOIL-INDUCED NON-B FORM - A THEORETICAL ANALYSIS [J] . Lahiri A., Majumdar R. Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena . 1996,第3期

机译：超螺旋诱导的非B形式的DNA配体结合等温线-理论分析
4. Reversible Transition of Photonic DNA Automaton Using Hairpin-DNA Responding to a Single Kind of Photonic Signal [C] . Hiroto Sakai, Yusuke Ogura, Jim Tanida Interntional Conference on DNA Computing and Molecular Programming . 2011

机译：光子DNA自动件使用发夹DNA响应单一光子信号的可逆转变
5. Effects of DNA Binding on the Structure of Bleomycin Analogs and DNA Hairpins Examined by NMR Spectroscopy. [D] . Follett, Shelby E. 2017

机译：DNA结合对博来霉素类似物和NMR光谱检查的DNA发夹结构的影响。
6. Supercoil-induced extrusion of a regulatory DNA hairpin [O] . Xing Dai, Miriam B. Greizerstein, Krisztina Nadas-Chinni, 1997

机译：超螺旋诱导的调控DNA发夹的挤出
7. Melting transition of covalently closed DNA with supercoil-induced cruciforms. [O] . Majumdar, R, Thakur, A R 1985

机译：超螺旋诱导的十字形共价闭合DNA的熔融转变。

SUPERCOIL-INDUCED EXTRUSION OF A REGULATORY DNA HAIRPIN

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