Induction by agrin of ectopic and functional postsynaptic-like membrane in innervated muscle

G. Jones; T. Meier; M. Lichtsteiner

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Induction by agrin of ectopic and functional postsynaptic-like membrane in innervated muscle

机译：凝集素诱导神经支配肌异位和功能性突触后样膜

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Two factors secreted from the nerve termi- nal, agrin and neuregulin, have been postulated to induce localization of the acetylcholine receptors (AChRs) to the subsynaptic membrane in skeletal muscle fibers. The princi- pal function ascribed to neuregulin is induction of AChR subunit gene expression and to agrin is the aggregation of AChRs. Here we report that when myoblasts engineered to secrete an agrin fragment were placed into the nerve-free region of denervated rodent muscle, the host muscle fibers expressed AChR -subunit gene transcripts, characteristic of the neuromuscular synapse in adult muscle.

机译：据推测，从神经末梢分泌的两个因子即凝集素和神经调节蛋白可诱导乙酰胆碱受体（AChRs）定位于骨骼肌纤维中的突触下膜。神经调节蛋白的主要功能是诱导AChR亚基基因表达，而凝集素的主要功能是AChR的聚集。在这里我们报告说，当工程改造成分泌凝集素片段的成肌细胞被放置在失神经的啮齿动物肌肉的无神经区域时，宿主肌肉纤维表达了AChR-亚基基因转录物，这是成年肌肉中神经肌肉突触的特征。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第6期|p.2654-2659|共6页
作者
G. Jones; T. Meier; M. Lichtsteiner;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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专利

1. INDUCTION BY AGRIN OF ECTOPIC AND FUNCTIONAL POSTSYNAPTIC-LIKE MEMBRANE IN INNERVATED MUSCLE [J] . Jones G., Lichtsteiner M., Witzemann V., Proceedings of the National Academy of Sciences of the United States of America . 1997,第6期

机译：肌内神经和功能性突触后膜的AGRIN诱导
2. Constitutively active MuSK is clustered in the absence of agrin and induces ectopic postsynaptic-like membranes in skeletal muscle fibers. [J] . Jones G, Moore C, Hashemolhosseini S, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 1999,第9期

机译：组成型活性MuSK在没有凝集素的情况下聚集，并在骨骼肌纤维中诱导异位突触后样膜。
3. Opposing effects of dexamethasone, agrin and sugammadex on functional innervation and constitutive secretion of IL-6 in in vitro innervated primary human muscle cells [J] . RezonjaK., LorenzonP., MarsT. Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2013,第Null期

机译：地塞米松，凝集素和sugammadex对体外受神经支配的原代人肌肉细胞中功能性神经支配和IL-6组成型分泌的相反作用
4. Biofabrication of Innervated Muscle Tissue for Accelerated Restoration of Muscle Function [C] . Hyun-Wook Kang, In Kap Ko, Cheil Kim, Society for Biomaterials annual meeting and exposition . 2013

机译：神经肌肉组织的生物制造，以加速恢复肌肉功能
5. Synaptic interactions of retrogradely labeled motoneurons that innervate the genioglossus muscle with substance P-like and delta opioid receptor-like immunoreactive nerve terminals. [D] . Richardson, Kimberlei A. 2003

机译：逆行标记的运动神经元与P状物质和δ阿片样物质受体样免疫反应性神经末梢神经支配的舌突肌的突触相互作用。
6. Induction by agrin of ectopic and functional postsynaptic-like membrane in innervated muscle [O] . G. Jones, T. Meier, M. Lichtsteiner, 1997

机译：凝集素诱导神经支配肌异位和功能性突触后样膜
7. Constitutively Active MuSK Is Clustered in the Absence of Agrin and Induces Ectopic Postsynaptic-Like Membranes in Skeletal Muscle Fibers [O] . Graham Jones, Chris Moore, Said Hashemolhosseini, 1999

机译：组成型活跃的麝香在没有agrin的情况下聚集在骨骼肌纤维中诱导异位后肌肉样膜

Induction by agrin of ectopic and functional postsynaptic-like membrane in innervated muscle

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