Regulation of E2F through ubiquitin-proteasome-dependent degradation: Stabilization by the pRB tumor suppressor protein

Miguel R. Campanero; Erik K. Flemington

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Regulation of E2F through ubiquitin-proteasome-dependent degradation: Stabilization by the pRB tumor suppressor protein

机译：通过泛素-蛋白酶体依赖性降解调节E2F：pRB肿瘤抑制蛋白的稳定作用

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The E2F family of transcription factors plays a key role in regulating cell-cycle progression. Accordingly, E2F is itself tightly controlled by a series of transcriptional and posttranscriptional events. Here we provide evidence that E2F1 protein levels are regulated by the ubiquitin- proteasome-dependent degradation pathway. An analysis of E2F1 mutants identified a conserved carboxyl-terminal re- gion, which is required for eliciting ubiquitination and protein turnover. Fusion of this E2F1 carboxyl-terminal sequence to a heterologous protein, GAL4, resulted in destabilization of GAL4.

机译：E2F转录因子家族在调节细胞周期进程中起关键作用。因此，E2F本身受到一系列转录和转录后事件的严格控制。在这里，我们提供证据表明E2F1蛋白水平受泛素-蛋白酶体依赖性降解途径调控。对E2F1突变体的分析确定了保守的羧基末端区域，这是引发泛素化和蛋白质更新所需的。此E2F1羧基末端序列与异源蛋白GAL4融合导致GAL4不稳定。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第6期|p.2221-2226|共6页
作者
Miguel R. Campanero; Erik K. Flemington;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. REGULATION OF E2F THROUGH UBIQUITIN-PROTEASOME-DEPENDENT DEGRADATION - STABILIZATION BY THE PRB TUMOR SUPPRESSOR PROTEIN [J] . Campanero MR., Flemington EK. Proceedings of the National Academy of Sciences of the United States of America . 1997,第6期

机译：PRB肿瘤抑制蛋白通过泛素依赖于蛋白质的降解-稳定化调控E2F
2. The extreme COOH terminus of the retinoblastoma tumor suppressor protein pRb is required for phosphorylation on Thr-373 and activation of E2f [J] . Laura L. Gorges, Nathan H. Lents, Joseph J. Baldassare American Journal of Physiology . 2008,第5aPta1期

机译：Rel-373的磷酸化需要视网膜母细胞瘤肿瘤抑制蛋白PRB的极端COOH末端，并激活E2F
3. The extreme COOH terminus of the retinoblastoma tumor suppressor protein pRb is required for phosphorylation on Thr-373 and activation of E2F [J] . Laura L. Gorges, Nathan H. Lents, Joseph J. Baldassare American Journal of Physiology . 2008,第5aPta1期

机译：视网膜母细胞瘤抑癌蛋白pRb的极端COOH末端是Thr-373上的磷酸化和E2F激活所必需的
4. Clustering Protein-Protein Interaction Network of TP53 Tumor Suppressor Protein using Markov Clustering Algorithm [C] . Thia Sabel Permata, Alhadi Bustamam International Conference on Advanced Computer Science and Information Systems . 2015

机译：使用Markov聚类算法的TP53肿瘤抑制蛋白的聚类蛋白 - 蛋白质相互作用网络
5. Regulation of the tumor suppressor pRB by protein kinase Cepsilon in human prostate cancer cells. [D] . Foreman, Tonia Lee. 2003

机译：蛋白激酶Cepsilon在人前列腺癌细胞中对抑癌基因pRB的调节。
6. Regulation of E2F through ubiquitin–proteasome-dependent degradation: Stabilization by the pRB tumor suppressor protein [O] . Miguel R. Campanero, Erik K. Flemington 1997

机译：通过泛素-蛋白酶体依赖性降解来调控E2F：pRB抑癌蛋白的稳定作用
7. Regulation of E2F through ubiquitin-proteasome-dependent degradation: Stabilization by the pRB tumor suppressor protein [O] . M. R. Campanero, E. K. Flemington 1997

机译：通过泛素 - 蛋白酶体依赖性降解调节E2F：PRB肿瘤抑制蛋白的稳定化
8. Structural Studies of the pRB Tumor Suppressor Complexed with Human Papillomavirus E7 Proteins [R] . Clements, A. 2000

机译：与人乳头瘤病毒E7蛋白复合的pRB肿瘤抑制因子的结构研究

Regulation of E2F through ubiquitin-proteasome-dependent degradation: Stabilization by the pRB tumor suppressor protein

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