Restrictive clonal allocation in the chimeric mouse brain

Chia-Yi Kuan; Eileen A. Elliott; Richard A. Flavell

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Restrictive clonal allocation in the chimeric mouse brain

机译：嵌合小鼠大脑中的限制性克隆分配

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Whether, and to what extent, lineage restric- tion contributes to the organization of the mammalian brain remains unclear. Here we address this issue by examining the distribution of clonally related cells in chimeric mice gener- ated by injecting genetically tagged embryonic stem (ES) cells into blastocyst embryos. Our examination of postnatal chi- meric brains revealed that the vast majority of labeled ES cell descendents were confined within a different subset of brain regions in each animal. Moreover, the deployment of labeled cells in different brain regions was distinctive.

机译：谱系限制是否以及在何种程度上有助于哺乳动物大脑的组织尚不清楚。在这里，我们通过检查通过将遗传标记的胚胎干（ES）细胞注入胚泡胚胎而产生的嵌合小鼠中克隆相关细胞的分布来解决这个问题。我们对产后嵌合体大脑的检查表明，大多数标记的ES细胞后代均被限制在每只动物的不同大脑区域内。此外，标记的细胞在不同大脑区域的部署也很独特。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第7期|p.3374-3379|共6页
作者
Chia-Yi Kuan; Eileen A. Elliott; Richard A. Flavell;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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专利

1. RESTRICTIVE CLONAL ALLOCATION IN THE CHIMERIC MOUSE BRAIN [J] . Kuan CY., Flavell RA., Rakic P., Proceedings of the National Academy of Sciences of the United States of America . 1997,第7期

机译：嵌合体小鼠脑中的限制性克隆分配
2. cDNA cloning and sequencing of a novel monoclonal antibody to carcinoembryonic antigen and construction of a mouse/human chimeric antibody. [J] . Shibaguchi H, Arakawa F, Imakiire T, Anticancer Research: International Journal of Cancer Research and Treatment . 2003,第6Appa期

机译：针对癌胚抗原的新型单克隆抗体的cDNA克隆和测序以及小鼠/人嵌合抗体的构建。
3. Cloning of mouse Ca(2+)/calmodulin-dependent protein kinase kinase beta (CaMKKbeta) and characterization of CaMKKbeta and CaMKKalpha distribution in the adult mouse brain. [J] . Vinet J, Carra S, Blom JM, Brain research. Molecular brain research . 2003,第1a2期

机译：小鼠Ca（2 +）/钙调蛋白依赖性蛋白激酶激酶β（CaMKKbeta）的克隆以及成年小鼠脑中CaMKKbeta和CaMKKalpha分布的表征。
4. Effect of cloned gene dosage on the expression level and stability of chimeric antibody producing CHO cells [C] . Sang Jick Kim, No Soo Kim, Hyo jeong Hong, Annual Meeting of the Japanese Association for Animal Cell Technology . 1998

机译：克隆基因剂量对嵌合抗体产生CHO细胞表达水平和稳定性的影响
5. Development of glial and neural specific clones for the analysis of protein L-isoasparytl methyl transferase expression in mouse brain. [D] . Eckstein, Veronica. 1998

机译：胶质和神经特异性克隆的发展，用于分析小鼠脑中蛋白L-异星丝菌甲基转移酶的表达。
6. Restrictive clonal allocation in the chimeric mouse brain [O] . Chia-Yi Kuan, Eileen A. Elliott, Richard A. Flavell, 1997

机译：嵌合小鼠脑中的限制性克隆分配
7. Structure of clonal and polyclonal cell arrays in chimeric mouse retina. [O] . Williams, R W, Goldowitz, D 1992

机译：嵌合小鼠视网膜中克隆和多克隆细胞阵列的结构。

Restrictive clonal allocation in the chimeric mouse brain

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