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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >TIME-COURSE CHANGES OF NERVE GROWTH FACTOR, CORTICOTROPIN-RELEASING HORMONE, AND NITRIC OXIDE SYNTHASE ISOFORMS AND THEIR POSSIBLE ROLE IN THE DEVELOPMENT OF INFLAMMATORY RESPONSE IN EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS
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TIME-COURSE CHANGES OF NERVE GROWTH FACTOR, CORTICOTROPIN-RELEASING HORMONE, AND NITRIC OXIDE SYNTHASE ISOFORMS AND THEIR POSSIBLE ROLE IN THE DEVELOPMENT OF INFLAMMATORY RESPONSE IN EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS

机译：神经变态因子，降结肠皮质激素和一氧化氮合酶同工酶的时程变化及其在实验性变态反应性脑脊髓炎炎症反应发展中的作用

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In this paper we report a time-course study of development of experimental allel gic encephalomyelitis in Lewis rats, by monitoring neuroendocrine regulation of the hypothalamus-pituitary-adrenal axis through corticotropin-releasing hormone mRNA expression, inflammatory cellular infiltrate, macrophagic and neuronal nitric oxide synthase, nerve growth factor (NGF), and NGF p75 and trkA receptors in the brain and spinal cord, We analyzed animals during 20 days after immunization, a time interval that corresponds to the acute immunological phase, We have described a severe, early fall of corticotropin-releasing hormone mRNA expression, which could account for the decreased response of the hypothalamus-pituitary-adrenal axis to inflammatory stress, During this period, an increase of neuronal nitric oxide synthase was observed in the cerebral cortex and spinal cord, and macrophagic nitric oxide synthase positive cells were found in the inflammatory cellular infiltrate, which was abundant in perivascular and submeningeal areas 20 days after immunization, Concomitantly, we found a dramatic up regulation of NGF receptors on the wall of blood vessels and adjacent neurons In perivascular areas, NGF content also had increased in some brain areas, such as the thalamus, while it had decreased in others, like the spinal cord and medulla oblongata, at time points in which the most serious cellular infiltrate was found. [References: 49]
机译：在本文中，我们通过监测促肾上腺皮质激素释放激素mRNA的表达，炎症细胞浸润，巨噬细胞和神经元一氧化氮的下丘脑-垂体-肾上腺轴的神经内分泌调节，来报道Lewis大鼠实验性变态反应性脑脊髓炎的发展过程。合酶，神经生长因子（NGF）以及脑和脊髓中的NGF p75和trkA受体，我们在免疫后20天（对应于急性免疫阶段的时间间隔）内对动物进行了分析，我们描述了严重的早期坠落促肾上腺皮质激素释放激素mRNA的表达，可能是下丘脑-垂体-肾上腺轴对炎性应激反应降低的原因。在此期间，大脑皮层和脊髓神经元一氧化氮合酶增加，巨噬细胞在炎性细胞浸润中发现一氧化氮合酶阳性细胞，在细胞中丰富。免疫后20天，在血管周围和脑膜下区域，我们发现血管壁和邻近神经元的NGF受体急剧上调。在血管周围区域，某些脑区域（如丘脑）的NGF含量也有所增加。在发现最严重的细胞浸润的时间点，其他疾病（例如脊髓和延髓）的血红蛋白下降。 [参考：49]

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