Human cytomegalovirus IE1 and IE2 proteins are mutagenic and mediate 'hit-and-run' oncogenic transformation in cooperation with the adenovirus E1A proteins

Yuqiao Shen; Hua Zhu; Thomas Shenk

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Human cytomegalovirus IE1 and IE2 proteins are mutagenic and mediate 'hit-and-run' oncogenic transformation in cooperation with the adenovirus E1A proteins

机译：人类巨细胞病毒IE1和IE2蛋白具有致突变性，并与腺病毒E1A蛋白协同介导“即席运行”致癌转化

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Some epidemiological studies have suggested a possible link between human cytomegalovirus (HCMV) infection and various malignancies, and HCMV has been shown to transform cultured cells. However, viral DNA is not detected in most transformants, and the mechanism by which HCMV might contribute to oncogenesis has remained ob- scure. Here we show that the HCMV immediate early 1 and 2 genes can cooperate with the adenovirus E1A gene to generate transformed foci of primary baby rat kidney cells.

机译：一些流行病学研究表明，人类巨细胞病毒（HCMV）感染与各种恶性肿瘤之间可能存在联系，并且已证明HCMV可以转化培养的细胞。但是，在大多数转化株中均未检测到病毒DNA，而HCMV可能促成肿瘤发生的机制仍不清楚。在这里，我们显示HCMV立即早期1和2基因可以与腺病毒E1A基因协同产生原代幼鼠肾细胞的转化灶。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第7期|p.3341-3345|共5页
作者
Yuqiao Shen; Hua Zhu; Thomas Shenk;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. HUMAN CYTOMEGALOVIRUS IE1 AND IE2 PROTEINS ARE MUTAGENIC AND MEDIATE HIT-AND-RUN ONCOGENIC TRANSFORMATION IN COOPERATION WITH THE ADENOVIRUS E1A PROTEINS [J] . Shen YQ., Shenk T., Zhu H. Proceedings of the National Academy of Sciences of the United States of America . 1997,第7期

机译：人巨细胞病毒IE1和IE2蛋白质是突变基因，可与腺病毒E1A蛋白质协同介导命中和运行致癌性转化
2. SUMO-1 modification of the major immediate-early (IE) 1 and 2 proteins of human cytomegalovirus is regulated by different mechanisms and modulates the intracellular localization of the IE1, but not IE2, protein. [J] . Sadanari H, Yamada R, Ohnishi K, Archives of virology . 2005,第9期

机译：人类巨细胞病毒的主要立即早期（IE）1和2蛋白的SUMO-1修饰受不同机制的调节，并调节IE1（而非IE2）蛋白的细胞内定位。
3. Distinct Roles for Human Cytomegalovirus Immediate Early Proteins IE1 and IE2 in the Transcriptional Regulation of MICA and PVR/CD155 Expression [J] . Pignoloni Benedetta, Fionda Cinzia, DellOste Valentina, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2016,第10期

机译：人巨细胞病毒立即早期蛋白IE1和IE2在云母和PVR / CD155表达的转录调控中的不同作用。
4. Differential compartmentalization of functional and structural proteins of human cytomegalovirus in nuclei and nuclear matrices of infected human embryo fibroblasts [C] . M.C. Arcangeletti, F. De Conto, F. Ferraglia, European Congress of Virology . 2004

机译：感染人胚胎成纤维细胞核和核基质中人巨细胞病毒功能和结构蛋白的差分分界化
5. Biological consequences of human cytomegalovirus IE1 and IE2 expression in rat cells. [D] . Bardales, Cheryl Yost. 1993

机译：人巨细胞病毒IE1和IE2在大鼠细胞中表达的生物学后果。
6. Human cytomegalovirus IE1 and IE2 proteins are mutagenic and mediate hit-and-run oncogenic transformation in cooperation with the adenovirus E1A proteins [O] . Yuqiao Shen, Hua Zhu, Thomas Shenk 1997

机译：人类巨细胞病毒IE1和IE2蛋白具有致突变性并与腺病毒E1A蛋白协同介导即席运行致癌转化
7. Proteasome-Independent Disruption of PML Oncogenic Domains (PODs), but Not Covalent Modification by SUMO-1, Is Required for Human Cytomegalovirus Immediate-Early Protein IE1 To Inhibit PML-Mediated Transcriptional Repression [O] . Xu, Yixun, Ahn, Jin-Hyun, Cheng, Mingfei, 2001

机译：PML致癌域（PODs）的蛋白酶体独立破坏，但不是SUMO-1的共价修饰，对于人类巨细胞病毒即早蛋白质IE1抑制PML介导的转录抑制是必需的。

Human cytomegalovirus IE1 and IE2 proteins are mutagenic and mediate 'hit-and-run' oncogenic transformation in cooperation with the adenovirus E1A proteins

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