cAMP-mediated inhibition of the epithelial brush border Na~+/H~+ exchanger, NHE3, requires an associated regulatory protein

C. H. Chris Yun; Soohyuk Oh; Mirza Zizak

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cAMP-mediated inhibition of the epithelial brush border Na~+/H~+ exchanger, NHE3, requires an associated regulatory protein

机译：cAMP介导的上皮刷状边界Na〜+ / H〜+交换子NHE3的抑制作用需要相关的调节蛋白

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NHE3 is the Na~+/H~+ exchanger located on the intestinal and renal brush border membrane, where it functions in transepithelial Na~+ absorption. The brush border Na~+ absorptive process is acutely inhibited by activation of cAMP-dependent protein kinase, but the molecular mecha- nism of this inhibitory effect is poorly understood. We have identified two regulatory proteins, E3KARP and NHERF, that interact with NHE3 to enable cAMP to inhibit NHE3. The two regulatory proteins are structurally related, sharing ≈50/100 identity in amino acid sequences.

机译：NHE3是位于肠和肾刷状边界膜上的Na〜+ / H〜+交换剂，在其中通过上皮吸收Na〜+。刷状缘Na〜+的吸收过程被cAMP依赖的蛋白激酶激活而被急性抑制，但是对该抑制作用的分子机理了解甚少。我们已经鉴定了两种调节蛋白，E3KARP和NHERF，它们与NHE3相互作用以使cAMP抑制NHE3。这两种调节蛋白在结构上相关，在氨基酸序列中具有约50/100的同一性。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第7期|p.3010-3015|共6页
作者
C. H. Chris Yun; Soohyuk Oh; Mirza Zizak;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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专利

1. CAMP-MEDIATED INHIBITION OF THE EPITHELIAL BRUSH BORDER NA+/H+ EXCHANGER, NHE3, REQUIRES AN ASSOCIATED REGULATORY PROTEIN [J] . Yun CHC., Zizak M., Steplock D., Proceedings of the National Academy of Sciences of the United States of America . 1997,第7期

机译：露营介导的上皮刷状鼻NA + / H +交换蛋白NHE3的抑制需要相关的调节蛋白
2. The epithelial brush border Na+/H+ exchanger NHE3 associates with the actin cytoskeleton by binding to ezrin directly and via PDZ domain-containing Na+/H+ exchanger regulatory factor (NHERF) proteins. [J] . Cha B, Donowitz M Clinical and experimental pharmacology & physiology . 2008,第8期

机译：上皮刷状边界Na + / H +交换子NHE3通过直接与ezrin结合并通过含PDZ域的Na + / H +交换子调节因子（NHERF）蛋白与肌动蛋白细胞骨架结合。
3. Differential Association of the Na+/H+ Exchanger Regulatory Factor (NHERF) Family of Adaptor Proteins with the Raft- and the Non-Raft Brush Border Membrane Fractions of NHE3 [J] . Chen M., deJonge H., Donowitz M., Cellular Physiology and Biochemistry . 2013,第5期

机译：Na + / H +交换调节因子（NHERF）衔接子蛋白家族与NHE3的筏和非筏刷边界膜部分的差异关联。
4. Inhibition of Serine-Threonine Protein Phosphatases in Monocyte Chemoattractant Protein-1 Expression in Helicobacter pylori-Stimulated Gastric Epithelial Cells [C] . HAE-YUN CHUNG, BORAM CHA, HYEYOUNG KIM Meeting on Cell Signaling World: Signal Transduction Pathways as Therapeutic Targets . 2007

机译：幽门螺杆菌刺激的胃上皮细胞单核细胞趋化蛋白-1表达中丝氨酸-苏氨酸蛋白磷酸酶的抑制。
5. Interaction of the baculovirus occlusion-derived virus envelope proteins ODV-E56 and ODV-E66 with the midgut brush border microvilli of the tobacco budworm, Heliothis virescens (Fabricius). [D] . Sparks, Wendy Olissa. 2010

机译：杆状病毒咬合来源的病毒包膜蛋白ODV-E56和ODV-E66与烟草芽虫中肠刷毛微绒毛菌（Heliothis virescens（Fabricius））的相互作用。
6. cAMP-mediated inhibition of the epithelial brush border Na+/H+ exchanger NHE3 requires an associated regulatory protein [O] . C. H. Chris Yun, Soohyuk Oh, Mirza Zizak, 1997

机译：cAMP介导的上皮刷状边界Na + / H +交换子NHE3的抑制作用需要相关的调节蛋白
7. cAMP-mediated inhibition of the epithelial brush border Na+/H+ exchanger, NHE3, requires an associated regulatory protein [O] . C. H. C. Yun, S. Oh, M. Zizak, 1997

机译：CAMP介导的上皮刷边缘NA + / H +交换器NHE3需要相关的调节蛋白

cAMP-mediated inhibition of the epithelial brush border Na~+/H~+ exchanger, NHE3, requires an associated regulatory protein

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