Essential role of the tyrosine kinase substrate phospholipase C-γ 1 in mammalian growth and development

Qun-sheng Ji; Glenn E. Winnier; Kevin D. Niswender

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Essential role of the tyrosine kinase substrate phospholipase C-γ 1 in mammalian growth and development

机译：酪氨酸激酶底物磷脂酶C-γ1在哺乳动物生长发育中的重要作用

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The activation of many tyrosine kinases leads to the phosphorylation and activation of phospholipase C-γ1 (PLC-γ1). To examine the biological function of this protein, homologous recombination has been used to selec- tively disrupt the Plcg1 gene in mice. Homozygous disruption of Plcg1 results in embryonic lethality at approximately embryonic day (E) 9.0. Histological analysis indicates that Plcg1 (-/-) embryos appear normal at E 8.5 but fail to continue normal development and growth beyond E 8.5-E9.0.

机译：许多酪氨酸激酶的激活导致磷脂酶C-γ1（PLC-γ1）的磷酸化和激活。为了检查这种蛋白质的生物学功能，已经使用同源重组选择性地破坏了小鼠中的Plcg1基因。 Plcg1的纯合破坏导致大约在胚胎第9.0天的胚胎致死率。组织学分析表明，Plcg1（-/-）胚胎在E 8.5时看起来正常，但在E 8.5-E9.0以后无法继续正常发育。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第7期|p.2999-3003|共5页
作者
Qun-sheng Ji; Glenn E. Winnier; Kevin D. Niswender;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. ESSENTIAL ROLE OF THE TYROSINE KINASE SUBSTRATE PHOSPHOLIPASE C-GAMMA-1 IN MAMMALIAN GROWTH AND DEVELOPMENT [J] . Ji QS., Niswender KD., Horstman D., Proceedings of the National Academy of Sciences of the United States of America . 1997,第7期

机译：酪氨酸激酶底物磷酸酶C-GAMMA-1在哺乳动物生长发育中的重要作用
2. Src-family kinases play an essential role in differentiation signaling downstream of macrophage colony-stimulating factor receptors mediating persistent phosphorylation of phospholipase C-|[gamma]|2 and MAP kinases ERK1 and ERK2 [J] . C Bourgin-Hierle, S Gobert-Gosse, J Thérier, Leukemia . 2008,第1期

机译：Src家族激酶在介导磷脂酶C- |γ| 2和MAP激酶ERK1和ERK2持续磷酸化的巨噬细胞集落刺激因子受体的下游信号传导中起重要作用。
3. Rapid Activation of Protein Tyrosine Kinase and Phospholipase C-γ2 and Increase in Cytosolic Free Calcium Are Required by Ehrlichia chaffeensis for Internalization and Growth in THP-1 Cells [J] . Mingqun Lin, Michael X. Zhu, Yasuko Rikihisa Infection and immunity . 2002,第2期

机译：酪氨酸埃里希氏菌需要蛋白质酪氨酸激酶和磷脂酶C-γ2的快速活化以及胞浆游离钙的增加才能在THP-1细胞内化和生长。
4. On the role of adenylate cyclase, tyrosine kinase and tyrosine phosphatase in the response of nerve and glial cells to photodynamic impact [C] . M. Kolosov, D. Bragin, O. Dergacheva, Conference on optical technologies in biophysics and medicine . 2004

机译：腺苷酸环酶，酪氨酸激酶和酪氨酸磷酸酶在神经和胶质细胞对光动力撞击响应中的作用
5. Src-family tyrosine kinases participate in the regulation of mammalian oocyte maturation and zygotic development. [D] . McGinnis, Lynda Kay. 2009

机译：Src家族酪氨酸激酶参与哺乳动物卵母细胞成熟和合子发育的调控。
6. Essential role of the tyrosine kinase substrate phospholipase C-γ1 in mammalian growth and development [O] . Qun-sheng Ji, Glenn E. Winnier, Kevin D. Niswender, 1997

机译：酪氨酸激酶底物磷脂酶C-γ1在哺乳动物生长发育中的重要作用
7. Essential role of the tyrosine kinase substrate phospholipase C- 1 in mammalian growth and development [O] . Q.-s. Ji, G. E. Winnier, K. D. Niswender, 1997

机译：酪氨酸激酶基质磷脂酶C- 1在哺乳动物生长发育中的基本作用

Essential role of the tyrosine kinase substrate phospholipase C-γ 1 in mammalian growth and development

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