...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >A cholera toxoid-insulin conjugate as an oral vaccine against spontaneous autoimmune diabetes
【24h】

A cholera toxoid-insulin conjugate as an oral vaccine against spontaneous autoimmune diabetes

机译：霍乱类毒素-胰岛素结合物作为自发性自身免疫性糖尿病的口服疫苗

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Mucosally induced immunological tolerance is an attractive strategy for preventing or treating illnesses resulting from untoward inflammatory immune reactions against self- or non-self-antigens. Oral administration of relevant autoantigens and allergens has been reported to delay or suppress onset of clinical disease in a number of experimental autoimmune and allergic disorders. However, the approach often requires repeated feeding of large amounts of tolerogens over long periods and is only partly effective in animals already systemically sensitized to the ingested antigen such as in animals already harboring autoreactive T cells, and thus presumably also in humans with an autoimmune disease.
机译：粘膜诱导的免疫耐受是用于预防或治疗由针对自身或非自身抗原的不良炎症免疫反应引起的疾病的有吸引力的策略。据报道，在许多实验性自身免疫和过敏性疾病中，口服相关的自身抗原和过敏原可延缓或抑制临床疾病的发作。但是，该方法通常需要长期反复喂食大量的致耐受原，并且仅对已经对摄入的抗原产生系统敏感性的动物（例如已经具有自身反应性T细胞的动物）部分有效，因此也可能对患有自身免疫性疾病的人有效。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号