Carcinogens induce reversion of the mouse pink-eyed unstable mutation

Robert H. Schiestl; Jiri Aubrecht; Fathia Khogali

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Carcinogens induce reversion of the mouse pink-eyed unstable mutation

机译：致癌物诱导小鼠粉红眼不稳定突变的逆转

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Deletions and other genome rearrangements are associated with carcinogenesis and inheritable diseases. The pink-eyed unstable (p~un) mutation in the mouse is caused by duplication of a 70-kb internal fragment of the p gene. Spontaneous reversion events in homozygous p~un/p~un mice occur through deletion of a duplicated sequence. Reversion events in premelanocytes in the mouse embryo detected as black spots on the gray fur of the offspring were inducible by the carcinogen x-rays, ethyl methanesulfonate, methyl meth- anesulfonate, ethyl nitrosourea, benzo[a]pyrene, trichloro- ethylene, benzene, and sodium arsenate.

机译：缺失和其他基因组重排与致癌作用和可遗传疾病有关。小鼠中的粉红色眼状不稳定（pun）突变是由p基因的70 kb内部片段重复引起的。纯合pun / pun小鼠中的自发回复事件是通过删除重复序列而发生的。致癌物X射线，甲磺酸乙酯，甲磺酸甲酯，亚硝基硫脲，苯并[a] py，三氯乙烯，苯引起了小鼠胚胎前黑素细胞的还原事件，该事件被检测为后代灰色皮毛上的黑斑。和砷酸钠。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第9期|p.4576-4581|共6页
作者
Robert H. Schiestl; Jiri Aubrecht; Fathia Khogali;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Benzo(a)pyrene and X-rays induce reversions of the pink-eyed unstable mutation in the retinal pigment epithelium of mice. [J] . Bishop AJ, Kosaras B, Sidman RL, Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects . 2000,第1a2期

机译：苯并（a）re和X射线可诱发小鼠视网膜色素上皮中粉红色眼不稳定突变的逆转。
2. Persistent induction of somatic reversions of the pink-eyed unstable mutation in F-1 mice born to fathers irradiated at the spermatozoa stage [J] . Shiraishi K., Shimura T., Taga M., Radiation Research: Official Organ of the Radiation Research Society . 2002,第6期

机译：持久诱导在精子阶段受照的父亲所生的F-1小鼠的粉红眼不稳定突变的体细胞逆转
3. Molecular analysis of 36 mutations at the mouse pink-eyed dilution (p) locus. [J] . C S Montgomery, C T Culiat, D K Johnson, Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation . 1995,第4期

机译：小鼠粉红眼稀释（p）基因座处36个突变的分子分析。
4. Repeated Ovarian Stimulations Induce Oxidative Damage and Mitochondrial DNA Mutations in Mouse Ovaries [C] . HSIANG-TAI CHAO, SHU-YU LEE, HORNG-MO LEE, Asian Society for Mitochondrial Research and Medicine . 2005

机译：反复卵巢刺激诱导小鼠卵巢中的氧化损伤和线粒体DNA突变
5. UV-Induced Somatic Mutations Elicit a Functional T Cell Response in the YUMMER1.7 Mouse Melanoma Model [D] . Wang, Jake Xiao. 2017

机译：紫外线诱导的体细胞突变在YUMMER1.7小鼠黑素瘤模型中引发功能性T细胞应答。
6. Carcinogens induce reversion of the mouse pink-eyed unstable mutation [O] . Robert H. Schiestl, Jiri Aubrecht, Fathia Khogali, 1997

机译：致癌物诱导小鼠粉红色眼球不稳定突变的逆转
7. High-frequency genetic reversion mediated by a DNA duplication: the mouse pink-eyed unstable mutation. [O] . Gondo, Y, Gardner, J M, Nakatsu, Y, 1993

机译：DNA复制介导的高频遗传回复：小鼠粉红眼不稳定突变。
8. Correlation of Carcinogenic Potency with Mouse-Skin (32)P-Postlabeling and Muta-(R)Mouse lac Z(-)Mutation Data for DMBA and Its K-Region Sulphur Isostere: Comparison with Activities Observed in Standard Genotoxicity Assays [R] . Ashby, J., Brusick, D., Myhr, B. C., 1993

机译：致癌效力与小鼠皮肤的相关性（32）p-标记后和muta-（R）小鼠lac Z（ - ）DmBa及其K区硫磺等位基因的突变数据：与标准基因毒性检测中观察到的活性的比较

Carcinogens induce reversion of the mouse pink-eyed unstable mutation

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