The active oligomeric state of the minimalistic influenza virus M_2 ion channel is a tetramer

Takemasa Sakaguchi; Qiang Tu; Lawrence H. Pinto

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The active oligomeric state of the minimalistic influenza virus M_2 ion channel is a tetramer

机译：简约流感病毒M_2离子通道的活性寡聚状态为四聚体

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The influenza A virus M_2 integral membrane protein is an ion channel that permits protons to enter virus particles during uncoating of virions in endosomes and also modulates the pH of the trans-Golgi network in virus-infected cells. The M_2 protein is a homo-oligomer of 97 residues, and analysis by chemical cross-linking and SDS/PAGE indicates M_2 forms a tetramer. However, a higher order molecular form is sometimes observed and, thus, it is necessary to determine the active form of the molecule.

机译：甲型流感病毒M_2整体膜蛋白是一个离子通道，该通道允许质子在核内体中的病毒体被覆过程中进入病毒颗粒，并且还调节病毒感染细胞中反式高尔基体网络的pH。 M_2蛋白是97个残基的均聚物，通过化学交联和SDS / PAGE分析表明M_2形成四聚体。然而，有时观察到更高阶的分子形式，因此，有必要确定分子的活性形式。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第10期|p.5000-5005|共6页
作者
Takemasa Sakaguchi; Qiang Tu; Lawrence H. Pinto;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. A functionally defined model for the M_2 proton channel of influenza A virus suggests a mechanism for its ion selectivity [J] . Lawrence H. Pinto, Gregg R. Dieckmann, Chris S. Gandhi Proceedings of the National Academy of Sciences of the United States of America . 1997,第21期

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2. Interdomain interactions in oligomeric enzymes: creation of asymmetry in homo‐oligomers and role in metabolite channeling between active centers of hetero‐oligomers [J] . Nagradova Natalya K FEBS Letters . 2001,第3期

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5. Influenza virus noninfectious biologically active particle subpopulations: Detection, quantification, genetic complexity, function and their novel use as an in vitro screen for self-adjuvating live-attenuated influenza vaccines. [D] . Ngunjiri, John Muthumbi. 2012

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6. The active oligomeric state of the minimalistic influenza virus M2 ion channel is a tetramer [O] . Takemasa Sakaguchi, Qiang Tu, Lawrence H. Pinto, 1997

机译：极简流感病毒M2离子通道的活性寡聚状态为四聚体
7. The Oligomeric State of the Active BM2 Ion Channel Protein of Influenza B Virus [O] . Victoria Balannik, Robert A. Lamb, Lawrence H. Pinto 2008

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8. Computer Simulation Studies of Ion Channel Gating: Characteristics of the M2 Channel of Influenza-A Virus in a Phospholipid Bilayer [R] . Schweighofer, Karl J., Pohorille, Andrew 1999

机译：离子通道门控的计算机模拟研究：磷脂双层流感病毒m2通道的特征

The active oligomeric state of the minimalistic influenza virus M_2 ion channel is a tetramer

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