Novel isoforms of the β and γ subunits of the Xenopus epithelial Na channel provide information about the amiloride binding site and extracellular sodium sensing

Alessandro Puoti; Anne May; Bernard C. Rossier

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Novel isoforms of the β and γ subunits of the Xenopus epithelial Na channel provide information about the amiloride binding site and extracellular sodium sensing

机译：爪蟾上皮Na通道β和γ亚基的新型同工型提供有关阿米洛利结合位点和细胞外钠感测的信息

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We have previously identified three homologous subunits α, β, and γ of the highly selective amiloride-sensitive Na channel from the Xenopus laevis kidney A6 cell line, which forms a tight epithelium in culture. We report here two novel genes, termed β2 and γ2, which share 90 and 92/100 sequence identity with the previously characterized β and γ XENaC, respectively. β2 and γ2 transcripts were detected in lung, kidney, and A6 cells grown on porous substrate. The

机译：我们以前从非洲爪蟾肾脏A6细胞系中鉴定出高度选择性的阿米洛利敏感的Na通道的三个同源亚基α，β和γ，它们在培养中形成紧密的上皮。我们在这里报告了两个新颖的基因，分别称为β2和γ2，它们分别与先前表征的β和γXENaC共享90和92/100序列同一性。在多孔基质上生长的肺，肾和A6细胞中检测到β2和γ2转录本。的

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第11期|p.5949-5954|共6页
作者
Alessandro Puoti; Anne May; Bernard C. Rossier;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Sodium self-inhibition of human epithelial sodium channel: selectivity and affinity of the extracellular sodium sensing site. [J] . Bize V, Horisberger JD American Journal of Physiology . 2007,第4期

机译：人上皮钠通道的钠自我抑制：细胞外钠传感位点的选择性和亲和力。
2. Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel [J] . Nandita S. Raikwar, Christie P. Thomas American Journal of Physiology . 2008,第5aPta2期

机译：Nedd4-2亚型泛素化单个上皮钠通道亚单位，并降低表面表达和上皮钠通道功能
3. Nedd4-2 isoforms ubiquitinate individual epithelial sodium channel subunits and reduce surface expression and function of the epithelial sodium channel [J] . Nandita S. Raikwar, Christie P. Thomas American Journal of Physiology . 2008,第5aPta2期

机译：Nedd4-2亚型泛素化单个上皮钠通道亚单位，并降低表面表达和上皮钠通道功能
4. Comparative modeling studies of rat amiloride-sensitive cation channel 1, neuronal isoform b [C] . Noureen N., Bano R., Rashid H. Emerging Technologies, 2009. ICET 2009 . 2009

机译：大鼠阿米洛利敏感阳离子通道1，神经元同工型b的比较建模研究
5. Characterization of an amiloride binding region in the alpha subunit of the epithelial sodium channel (ENaC). [D] . Kelly, Ollie. 2003

机译：上皮钠通道（ENaC）的alpha亚基中阿米洛利结合区的特征。
6. Novel isoforms of the β and γ subunits of the Xenopus epithelial Na channel provide information about the amiloride binding site and extracellular sodium sensing [O] . Alessandro Puoti, Anne May, Bernard C. Rossier, 1997

机译：爪蟾上皮Na通道β和γ亚基的新型同工型提供有关阿米洛利结合位点和细胞外钠传感的信息
7. The Amiloride-sensitive Epithelial Sodium Channel α-Subunit Is Transcriptionally Down-regulated in Rat Parotid Cells by the Extracellular Signal-regulated Protein Kinase Pathway [O] . Mark D. Zentner, H. Helen Lin, Xin Wen, 1998

机译：通过细胞外信号调节蛋白激酶途径在大鼠腮腺细胞中转录余静敏感上皮钠通道α-亚基

Novel isoforms of the β and γ subunits of the Xenopus epithelial Na channel provide information about the amiloride binding site and extracellular sodium sensing

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