BCL8, a novel gene involved in translocations affecting band 15q11-13 in diffuse large-cell lymphoma

Vadim G. Dyomin; Pulivarthi H. Rao; Riccardo Dalla-Favera

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BCL8, a novel gene involved in translocations affecting band 15q11-13 in diffuse large-cell lymphoma

机译：BCL8，一种涉及易位的新基因，可影响弥漫性大细胞淋巴瘤的15q11-13带

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Translocations affecting the chromosomal region 15q11-13 and various other partners are recurrent in diffuse large-cell lymphomas (DLCL). To identify the putative gene, here named BCL8, involved in these translocations we have cloned the breakpoint region from a DLCL patient with t(14;15)(q32;q11-13) and the corresponding germ-line region from chromosome 15. The genomic locus on chromosome 15 is clonally rearranged in about 4/100 of DLCL in agreement with the frequency of 15q11-13 translocations.

机译：在弥漫性大细胞淋巴瘤（DLCL）中经常发生易位，影响染色体区域15q11-13和其他各种伴侣。为了鉴定参与这些易位的推定基因（此处称为BCL8），我们克隆了一名患有t（14; 15）（q32; q11-13）的DLCL患者的断点区域以及来自15号染色体的相应种系区域。与15q11-13易位的频率一致，第15号染色体上的基因组基因座在DLCL的约4/100中被克隆重排。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第11期|p.5728-5732|共5页
作者
Vadim G. Dyomin; Pulivarthi H. Rao; Riccardo Dalla-Favera;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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2. Codeletion of CDKN2 and MTAP genes in a subset of non-Hodgkin's lymphoma may be associated with histologic transformation from low-grade to diffuse large-cell lymphoma. [J] . Dreyling MH, Roulston D, Bohlander SK, Genes, Chromosomes and Cancer . 1998,第1期

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机译：免疫调节药物来那度胺在淋巴瘤患者中的安全性和有效性：RU051417I-R-ICE（利妥昔单抗-异环磷酰胺-卡铂-依托泊苷）与来那度胺[R2-ICE]的I / II期开放标签研究的进展初次复发/原发性难治性弥漫性大B细胞淋巴瘤（DLBCL）。
6. BCL8 a novel gene involved in translocations affecting band 15q11–13 in diffuse large-cell lymphoma [O] . Vadim G. Dyomin, Pulivarthi H. Rao, Riccardo Dalla-Favera, 1997

机译：BCL8一种新基因参与易位影响弥漫性大细胞淋巴瘤的15q11-13带
7. Deregulation of PAX-5 by translocation of the Emu enhancer of the IgH locus adjacent to two alternative PAX-5 promoters in a diffuse large-cell lymphoma. [O] . Busslinger, M, Klix, N, Pfeffer, P, 1996

机译：在弥漫性大细胞淋巴瘤中，通过与两个备选PAX-5启动子相邻的IgH基因座的mu增强子的易位，来解除PAX-5的调节。

BCL8, a novel gene involved in translocations affecting band 15q11-13 in diffuse large-cell lymphoma

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