Skn-1: Evidence for a bipartite recognition helix in DNA binding

Santona Pal; Mei-Chu Lo; Darby Schmidt

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Skn-1: Evidence for a bipartite recognition helix in DNA binding

机译：Skn-1：DNA结合中双分子识别螺旋的证据

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Skn-1 is a maternally expressed transcrip- tion factor that specifies the fate of certain blastomeres early in the development of Caenorhabditis elegans. This transcrip- tion factor contains a basic region, but it binds to DNA as a monomer. Because other transcription factors containing basic regions bind as dimers, this finding implied that Skn represents a new DNA recognition motif. It has been proposed that the basic region helix of Skn is stabilized for binding by tertiary contacts to other parts of the protein. We have tested this proposal by carrying out circular dichroism (CD) and NMR experiments on the Skn domain and five truncated proteins.

机译：Skn-1是母体表达的转录因子，可确定秀丽隐杆线虫在早期发育中某些卵裂球的命运。该转录因子包含一个基本区域，但它作为单体与DNA结合。因为其他包含基本区域的转录因子以二聚体形式结合，所以这一发现暗示Skn代表了新的DNA识别基序。已经提出，Skn的基本区域螺旋被稳定，以通过三级接触与蛋白质的其他部分结合。我们已经通过对Skn结构域和五个截短蛋白进行圆二色性（CD）和NMR实验来测试了该建议。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第11期|p.5556-5561|共6页
作者
Santona Pal; Mei-Chu Lo; Darby Schmidt;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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专利

1. Evidence that the DNA binding specificity of winged helix proteins is mediated by a structural change in the amino acid sequence adjacent to the principal DNA binding helix [J] . Marsden I, Chen Y, Jin C, Biochemistry . 1997,第43期

机译：有翅螺旋蛋白的DNA结合特异性是由与主要DNA结合螺旋相邻的氨基酸序列的结构改变所介导的证据
2. Structural basis of DNA recognition by PCG2 reveals a novel DNA binding mode for winged helix-turn-helix domains [J] . Liu Junfeng, Huang Jinguang, Zhao Yanxiang, Nucleic Acids Research . 2015,第2期

机译：PCG2识别DNA的结构基础揭示了有翼螺旋-转-螺旋结构域的新型DNA结合模式
3. Structural basis of DNA recognition by PCG2 reveals a novel DNA binding mode for winged helix-turn-helix domains [J] . Dawei Wang, Huaian Liu, Ian A. Taylor, Nucleic acids research . 2015,第2期

机译：PCG2识别DNA的结构基础揭示了有翼螺旋-转-螺旋结构域的新型DNA结合模式
4. Conversion Of Helix-turn-helix Motif Sequence-specific DNA Binding Proteins Into Site-specific DNA Cleavage Agents [C] . Ebright R.H., Ebright Y.W., Pendergrast P.S., Engineering in Medicine and Biology Society, 1990., Proceedings of the Twelfth Annual International Conference of the IEEE . 1990

机译：螺旋转螺旋基序序列特定的DNA结合蛋白到位点特异性DNA裂解剂的转换。
5. Inhibitor of DNA binding/differentiation (ID) helix-loop-helix proteins mediate BMP-induced osteoblast lineage-specific differentiation of mesenchymal stem cells. [D] . Peng, Ying. 2005

机译：DNA结合/分化（ID）抑制剂螺旋-环-螺旋蛋白介导BMP诱导的间充质干细胞的成骨细胞谱系特异性分化。
6. Skn-1: Evidence for a bipartite recognition helix in DNA binding [O] . Santona Pal, Mei-Chu Lo, Darby Schmidt, 1997

机译：Skn-1：DNA结合中二分识别螺旋的证据
7. The helix-hairpin-helix DNA-binding motif: a structural basis for non-sequence-specific recognition of DNA. [O] . Doherty, A J, Serpell, L C, Ponting, C P 1996

机译：螺旋-发夹-螺旋DNA结合基序：DNA的非序列特异性识别的结构基础。

Skn-1: Evidence for a bipartite recognition helix in DNA binding

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