In vivo role of B lymphocytes in somatic transgene immunization

Sidong Xiong; Mara Gerloni; Maurizio Zanetti

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In vivo role of B lymphocytes in somatic transgene immunization

机译：B淋巴细胞在体细胞转基因免疫中的体内作用

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Immunity generated by in vivo inoculation of plasmid DNA is a straightforward and potentially valuable new approach to immunization. Little is known about the type of cells involved, the various immunological aspects, and the destiny of the transgene. In this report, we describe a system in which immunity is the result of in vivo targeting of B lymphocytes. This was accomplished using plasmid DNA encoding an immunoglobulin heavy-chain gene under the control of immunoglobulin promoter and enhancer elements.

机译：通过体内接种质粒DNA产生的免疫力是一种直接且具有潜在价值的新型免疫方法。关于所涉及的细胞类型，各种免疫学方面以及转基因的命运知之甚少。在这份报告中，我们描述了一种系统，其中免疫力是体内针对B淋巴细胞的结果。这是通过在免疫球蛋白启动子和增强子元件的控制下使用编码免疫球蛋白重链基因的质粒DNA来完成的。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第12期|p.6352-6357|共6页
作者
Sidong Xiong; Mara Gerloni; Maurizio Zanetti;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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2. Studies on CD4 T cell immunity using somatic transgene immunization. [J] . Gerloni M, Zanetti M International reviews of immunology . 2001,第5期

机译：使用体细胞转基因免疫研究CD4 T细胞免疫。
3. Expression of a bcl-2 transgene reduces proliferation and slows turnover of developing B lymphocytes in vivo. [J] . OReilly LA, Harris AW, Tarlinton DM, The Journal of Immunology: Official Journal of the American Association of Immunologists . 1997,第5期

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6. In vivo role of B lymphocytes in somatic transgene immunization [O] . Sidong Xiong, Mara Gerloni, Maurizio Zanetti 1997

机译：B淋巴细胞在体细胞转基因免疫中的体内作用
7. The comparative in vitro and in vivo activity of antilymphocyte serum raised by immunization with thymic, splenic, and lymph node lymphocytes [O] . Ono K, Bell P, Kashiwagi N, 1969

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In vivo role of B lymphocytes in somatic transgene immunization

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