Promoter analysis in living zebrafish embryos identifies a cis-acting motif required for neuronal expression of GATA-2

Anming Meng; Hong Tang; Bruce A. Ong

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Promoter analysis in living zebrafish embryos identifies a cis-acting motif required for neuronal expression of GATA-2

机译：斑马鱼活体胚胎中的启动子分析确定了GATA-2神经元表达所需的顺式作用基序

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We have used zebrafish embryos to dissect the promoter activity of a gene with a complex expression pattern during embryogenesis. GATA-2 is a transcription factor required for hematopoiesis and is dynamically ex- pressed in hematopoietic tissues and in the central nervous system. Using constructs containing zebrafish GATA-2 genomic flanking sequences and the green fluorescent protein (GFP) reporter gene, we demonstrate that distinct regulatory domains are required for hematopoietic, enveloping layer (EVL), and neuronal expression of GATA-2.

机译：我们已经使用斑马鱼胚胎解剖胚胎发生过程中具有复杂表达模式的基因的启动子活性。 GATA-2是造血所需的转录因子，在造血组织和中枢神经系统中动态表达。使用包含斑马鱼GATA-2基因组侧翼序列和绿色荧光蛋白（GFP）报告基因的构建体，我们证明了GATA-2的造血，包膜层（EVL）和神经元表达需要不同的调节域。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第12期|p.6267-6272|共6页
作者
Anming Meng; Hong Tang; Bruce A. Ong;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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6. Promoter analysis in living zebrafish embryos identifies a cis-acting motif required for neuronal expression of GATA-2 [O] . Anming Meng, Hong Tang, Bruce A. Ong, 1997

机译：斑马鱼活体胚胎中的启动子分析确定了GATA-2神经元表达所需的顺式作用基序
7. Figure S1: Motif logo for the identified promoters motif logo. (a) BM5 phage-RNP promoters motif logo, (b) BM10 phage-RNP promoters and Bacillus (host)-RNP promoters motif logo [O] . -1

机译：图S1：识别的启动子主题徽标的图案标识。（a）BM5噬菌体RNP启动子MOTIF LOGO，（B）BM10噬菌体 - RNP启动子和芽孢杆菌（宿主）-RNP启动子主题徽标

Promoter analysis in living zebrafish embryos identifies a cis-acting motif required for neuronal expression of GATA-2

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