Ancient origin of the complement lectin pathway revealed by molecular cloning of mannan binding protein-associated serine protease from a urochordate, the Japanese ascidian, Halocynthia roretzi

Xin Ji; Kaoru Azumi; Makoto Sasaki

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Ancient origin of the complement lectin pathway revealed by molecular cloning of mannan binding protein-associated serine protease from a urochordate, the Japanese ascidian, Halocynthia roretzi

机译：补体凝集素途径的古代起源是通过分子克隆甘露聚糖结合蛋白相关的丝氨酸蛋白酶而揭示的，该丝氨酸蛋白酶来自一种urochordate，日本海鞘，Halocynthia roretzi

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Recent identification of a C3-like gene in sea urchins revealed the presence of a complement system in invertebrates. To elucidate further the components and func- tion of the pre-vertebrate complement system, we attempted to isolate an ascidian (urochordata) C3 convertase. After iden- tification of C3 cDNA from Halocynthia roretzi, a Japanese ascidian, reverse transcriptase-PCR amplification of hepa- topancreas RNA was performed using primers encoding highly conserved amino acid sequences of the vertebrate Bf and C2 serine protease domain.

机译：最近在海胆中鉴定出一个类似于C3的基因，这表明无脊椎动物中存在补体系统。为了进一步阐明椎骨前补体系统的组成和功能，我们试图分离一种海鞘（urochordata）C3转化酶。鉴定出日本轮虫（Halocynthia roretzi）的C3 cDNA后，用编码脊椎动物Bf和C2丝氨酸蛋白酶结构域高度保守的氨基酸序列的引物进行了肝胰腺RNA的逆转录酶PCR扩增。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第12期|p.6340-6345|共6页
作者
Xin Ji; Kaoru Azumi; Makoto Sasaki;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. An Ancient Lectin-Dependent Complement System in an Ascidian: Novel Lectin Isolated from the Plasma of the Solitary Ascidian, Halocynthia roretzi [J] . Hideharu Sekine, Akira Kenjo, Kaoru Azumi, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2001,第8期

机译：在海鞘中一个古老的依赖凝集素的补体系统：从孤独的海鞘血浆中分离出的新型凝集素，Halocynthia roretzi
2. An Ancient Lectin-Dependent Complement System in an Ascidian: Novel Lectin Isolated from the Plasma of the Solitary Ascidian, Halocynthia roretzi [J] . Hideharu Sekine, Akira Kenjo, Kaoru Azumi, The journal of immunology . 2001,第8期

机译：在海鞘中一个古老的凝集素依赖性补体系统：从孤独的海鞘血浆中分离出的新型凝集素，Halocynthia roretzi
3. Lectin pathway effector enzyme mannan-binding lectin-associated serine protease-2 can activate native complement C3 in absence of C4 and/or C2 [J] . Sadam Yaseen, Gregory Demopulos, Thomas Dudler, The FASEB Journal . 2017,第5期

机译：凝集素途径效应酶甘露聚糖结合凝集素相关的丝氨酸蛋白酶2可以在没有C4和/或C2的情况下激活天然补体C3
4. Ancient origin of the complement lectin pathway revealed by molecular cloning of mannan binding protein-associated serine protease from a urochordate the Japanese ascidian Halocynthia roretzi [O] . Xin Ji, Kaoru Azumi, Makoto Sasaki, 1997

机译：补体凝集素途径的远古起源是通过分子克隆甘露聚糖结合蛋白相关的丝氨酸蛋白酶而揭示的该丝氨酸蛋白酶来自一种urochordate日本海鞘Halocynthia roretzi
5. An Ancient Lectin-Dependent Complement System in an Ascidian: Novel Lectin Isolated from the Plasma of the Solitary Ascidian, Halocynthia roretzi [O] . Hideharu Sekine, Akira Kenjo, Kaoru Azumi, 2001

机译：阿立迪亚山脉的古代依赖补充系统：从孤立的孤立的血浆孤立的新凝集素，Halocynthia Roretzi

Ancient origin of the complement lectin pathway revealed by molecular cloning of mannan binding protein-associated serine protease from a urochordate, the Japanese ascidian, Halocynthia roretzi

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