Cleft palate and decreased brain -aminobutyric acid in mice lacking the 67-kDa isoform of glutamic acid decarboxylase

Hideo Asada; Yuuki Kawamura; Kei Maruyama

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Cleft palate and decreased brain -aminobutyric acid in mice lacking the 67-kDa isoform of glutamic acid decarboxylase

机译：缺乏谷氨酸脱羧酶67-kDa亚型的小鼠的pa裂和脑氨基丁酸减少

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In addition to its role as an inhibitory neu- rotransmitter, γ-aminobutyric acid (GABA) is presumed to be involved in the development and plasticity of the nervous system. GABA is synthesized by glutamic acid decarboxylase (GAD), but the respective roles of its two isoforms (GAD65 and 67) have not been determined. The selective elimination of each GAD isoform by gene targeting is expected to clarify these issues.

机译：γ-氨基丁酸（GABA）除了具有抑制神经递质的作用外，还被认为与神经系统的发育和可塑性有关。 GABA由谷氨酸脱羧酶（GAD）合成，但尚未确定其两种同工型（GAD65和67）的各自作用。通过基因靶向选择性消除每个GAD同工型有望阐明这些问题。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第12期|p.6496-6499|共4页
作者
Hideo Asada; Yuuki Kawamura; Kei Maruyama;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Cleft palate in mice with a targeted mutation in the γ -aminobutyric acid-producing enzyme glutamic acid decarboxylase 67 [J] . Brian G. Condie, Gerard Bain, David I. Gottlieb Proceedings of the National Academy of Sciences of the United States of America . 1997,第21期

机译：产生γ-氨基丁酸的酶谷氨酸脱羧酶的目标突变的小鼠裂67
2. Disturbance of neural respiratory control in neonatal mice lacking gaba synthesizing enzyme 67-kDa isoform of glutamic acid decarboxylase. [J] . Kuwana S, Okada Y, Sugawara Y, Neuroscience: An International Journal under the Editorial Direction of IBRO . 2003,第3期

机译：缺乏gaba合成酶谷氨酸脱羧酶67-kDa亚型的新生小鼠的神经呼吸控制障碍。
3. Development of the GABA system in organotypic culture of hippocampal and cerebellar slices from a 67-kDa isoform of glutamic acid decarboxylase (GAD67)-deficient mice. [J] . Ji F, Obata K Neuroscience Research: The Official Journal of the Japan Neuroscience Society . 1999,第3期

机译：谷氨酸脱羧酶（GAD67）缺陷型小鼠的67 kDa亚型海马和小脑切片器官型培养中GABA系统的开发。
4. Effects of Lactobacillus acidophilus strain L-55 on steroid-induced cleft palates in ICR mice [C] . T. Yamada, T. Yamamoto, D. Janune, International Congress on Cleft Lip and Palate and Related Craniofacial Anomalies . 2009

机译：乳杆菌酸痛L-55对ICR小鼠类固醇诱导的腭裂的影响
5. GLUTAMIC ACID DECARBOXYLASE AND THE GAMMA-AMINOBUTYRIC ACID PATHWAY IN THE SUPRAESOPHAGEAL GANGLION OF THE HONEYBEE, APIS MELLIFERA (HYMENOPTERA, APIDAE). [D] . FOX, PHILIP MICHAEL. 1970

机译：蜜蜂APIS MELLIFERA（膜翅目，APIDAE）的食管神经节中的谷氨酸脱羧酶和γ-氨基丁酸途径。
6. Cleft palate and decreased brain γ-aminobutyric acid in mice lacking the 67-kDa isoform of glutamic acid decarboxylase [O] . Hideo Asada, Yuuki Kawamura, Kei Maruyama, 1997

机译：缺乏谷氨酸脱羧酶67-kDa亚型的小鼠的left裂和大脑γ-氨基丁酸减少
7. Cleft palate in mice with a targeted mutation in the -aminobutyric acid-producing enzyme glutamic acid decarboxylase 67 [O] . B. G. Condie, G. Bain, D. I. Gottlieb, 1997

机译：小鼠中腭裂，具有 - 氨基丁酸的酶谷氨酸脱羧酶67中具有靶向突变
8. Inhibition of Glutamic Acid Decarboxylase and gamma-Aminobutyric Acid Transaminase by Sodium Cyanide. [R] . Cassel, G., Karlsson, L., Sellstroem, A. 1991

机译：用氰化钠抑制谷氨酸脱羧酶和γ-氨基丁酸转氨酶。

Cleft palate and decreased brain -aminobutyric acid in mice lacking the 67-kDa isoform of glutamic acid decarboxylase

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