The interferon-inducible murine p48 (ISGF3γ) gene is regulated by protooncogene c-myc

Xiao Weihua; Daniel J. Lindner; Dhananjaya V. Kalvakolanu

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The interferon-inducible murine p48 (ISGF3γ) gene is regulated by protooncogene c-myc

机译：干扰素诱导的鼠p48（ISGF3γ）基因受原癌基因c-myc调控

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p48 protein is an integral component of the multimeric interferon (IFN)-regulated transcription factor, ISGF3. We have shown earlier that this gene is regulated by a novel IFN-γ-regulated element. In addition to the IFN- regulated element, a myc-max binding site is also present in this promoter. In this investigation we have studied the role of this site in the regulation of the p48 gene. In serum-induced quiescent cells Myc up-regulated the expression of p48 mRNA. We show that the protooncogene Myc regulates the expression of p48 through the element CACGTG.

机译：p48蛋白是多聚体干扰素（IFN）调节的转录因子ISGF3的组成部分。前面我们已经表明，该基因受新型IFN-γ调控元件的调控。除了IFN调节的元件，myc-max结合位点也存在于该启动子中。在这项研究中，我们研究了该位点在p48基因调控中的作用。在血清诱导的静止细胞中，Myc上调了p48 mRNA的表达。我们显示原癌基因Myc通过CACGTG元件调节p48的表达。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第14期|p.7227-7232|共6页
作者
Xiao Weihua; Daniel J. Lindner; Dhananjaya V. Kalvakolanu;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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专利

1. Interferon γ-induced transcription of the murine ISGF3γ (p48) gene is mediated by novel factors [J] . Xiao Weihua, Venkatadri Kolla, Dhananjaya V. Kalvakolanu Proceedings of the National Academy of Sciences of the United States of America . 1997,第1期

机译：干扰素γ诱导的鼠ISGF3γ（p48）基因转录是由新因子介导的
2. The c-MYC Protooncogene Expression in Cholesteatoma [J] . Eniko Palko, Szilard Poliska, Zsuzsanna Csakanyi, BioMed research international . 2014,第4期

机译：胆脂瘤中c-MYC原癌基因的表达
3. The c-MYC Protooncogene Expression in Cholesteatoma [J] . Enik?Palkó, SzilárdPóliska, ZsuzsannaCsákányi, BioMed research international . 2014,第1期

机译：胆脂瘤中c-MYC原癌基因的表达
4. Desorption Electrospray Ionization Imaging: Identification of Lipid Species Regulated by the c-MYC Oncogene [C] . Ali I. Ismail, Richard H. Perry, Emelyn H. Shroff, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：解吸电喷雾电离成像：鉴定C-MYC癌基因调节的脂质物种
5. CD40 regulation of nuclear factor-kappa B/Rel and c-myc expression and their involvement in apoptosis of murine B cells. [D] . Schauer, Stephanie Lynn. 1997

机译：CD40调节核因子-κB/ Rel和c-myc表达，并参与鼠B细胞的凋亡。
6. The interferon-inducible murine p48 (ISGF3γ) gene is regulated by protooncogene c-myc [O] . Xiao Weihua, Daniel J. Lindner, Dhananjaya V. Kalvakolanu 1997

机译：干扰素诱导的鼠p48（ISGF3γ）基因受原癌基因c-myc调控
7. Pleiotropic derepression of developmentally regulated cellular and viral genes by c-myc protooncogene products in undifferentiated embryonal carcinoma cells. [O] . Onclercq, R, Lavenu, A, Cremisi, C 1989

机译：c-myc原癌基因产物在未分化的胚胎癌细胞中多向抑制发育调节的细胞和病毒基因。
8. Multiple Mechanisms Regulate c-myc Gene Expression during Normal T Cell Activation [R] . Lindsten, T., June, C. H., Thompson, C. B. 1988

机译：多种机制调节正常T细胞活化期间的c-myc基因表达

The interferon-inducible murine p48 (ISGF3γ) gene is regulated by protooncogene c-myc

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