Interaction between replication protein A and p53 is disrupted after UV damage in a DNA repair-dependent manner

Natalia A. Abramova; Jackie Russell; Michael Botchan

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Interaction between replication protein A and p53 is disrupted after UV damage in a DNA repair-dependent manner

机译：紫外线损伤后，复制蛋白A和p53之间的相互作用以DNA修复依赖性方式被破坏

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Replication protein A (RPA) is required for both DNA replication and nucleotide excision repair. Previous studies have shown that RPA interacts with the tumor sup- pressor p53. Herein, we have mapped a 20-amino acid region in the N-terminal part of p53 that is essential for its binding to RPA. This region is distinct from the minimal activation domain of p53 previously identified. We also demonstrate that UV radiation of cells greatly reduces the ability of RPA to bind to p53. Interestingly, damage-induced hyperphosphorylated RPA does not associate with p53.

机译：DNA复制和核苷酸切除修复均需要复制蛋白A（RPA）。先前的研究表明，RPA与肿瘤抑制因子p53相互作用。在本文中，我们在p53的N端部分绘制了一个20个氨基酸的区域，该区域对其与RPA的结合至关重要。该区域不同于先前鉴定的p53的最小激活结构域。我们还证明了细胞的紫外线辐射大大降低了RPA与p53结合的能力。有趣的是，损伤诱导的高磷酸化RPA与p53不相关。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第14期|p.7186-7191|共6页
作者
Natalia A. Abramova; Jackie Russell; Michael Botchan;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Characterization of DNA Binding Activity,Protein Interactions,and Activity in DNA Replication and Repair DNA Damage Induced Hyperphosphorylation of Replication Protein A.2. [J] . Steve M.Patrick, Greg G.Oakley, Kathleen Dixon, Biochemistry . 2005,第23期

机译：DNA结合活性的表征，蛋白质相互作用和DNA复制中的活性和修复DNA损伤诱导复制蛋白A.2的超磷酸化。
2. DNA damage induced hyperphosphorylation of replication protein A. 2. Characterization of DNA binding activity, protein interactions, and activity in DNA replication and repair [J] . Patrick SM, Oakley GG, Dixon K, Biochemistry . 2005,第23期

机译：DNA损伤引起复制蛋白A的过度磷酸化。2. DNA结合活性，蛋白相互作用以及DNA复制和修复活性的表征
3. UV light-damaged DNA and its interaction with human replication protein A: an atomic force microscopy study [J] . M. Lysetska, A. Knoll, D. Boehringer, Nucleic Acids Research . 2002,第12期

机译：紫外线破坏的DNA及其与人类复制蛋白A的相互作用：原子力显微镜研究
4. Mapping Protein-DNA Interactions Using UV Crosslinking and Mass Spectrometry [C] . Fiona Flett, David Clarke, Pat Langridge-Smith, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：使用UV交联和质谱法测定蛋白质-DNA相互作用
5. Single molecule studies of damaged recognition by the human UV-damaged DNA-binding protein (UV-DDB) [D] . Ghodke, Harshad 2013

机译：人类紫外线损伤的DNA结合蛋白（UV-DDB）识别识别受损的单分子研究
6. Interaction between replication protein A and p53 is disrupted after UV damage in a DNA repair-dependent manner [O] . Natalia A. Abramova, Jackie Russell, Michael Botchan, 1997

机译：DNA修复依赖的方式中紫外线破坏后复制蛋白A和p53之间的相互作用被破坏。
7. FANCJ Helicase Uniquely Senses Oxidative Base Damage in Either Strand of Duplex DNA and Is Stimulated by Replication Protein A to Unwind the Damaged DNA Substrate in a Strand-specific Manner* [O] . Suhasini, Avvaru N., Sommers, Joshua A., Mason, Aaron C., 2009

机译：FANCJ解旋酶独特地感知双链DNA任一链中的氧化性碱基损伤，并受到复制蛋白A的刺激，以特定于链的方式解开受损的DNA底物*
8. Involvement of 53BP1, a p53 Binding Protein, in Chk2 Phosphyorylation of p53 and DNA Damage Cell Cycle Checkpoints [R] . Wang, B. 2006

机译：p53结合蛋白53Bp1参与p53和DNa损伤的Chk2磷酸化细胞周期检查点

Interaction between replication protein A and p53 is disrupted after UV damage in a DNA repair-dependent manner

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