Ceramide-induced inhibition of T lymphocyte voltage-gated potassium channel is mediated by tyrosine kinases

Erich Gulbins; Ildiko Szabo; Katharina Baltzer

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Ceramide-induced inhibition of T lymphocyte voltage-gated potassium channel is mediated by tyrosine kinases

机译：神经酰胺诱导的T淋巴细胞电压门控钾通道抑制作用是由酪氨酸激酶介导的

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The n-type K~+ channel (n-K~+, Kv1.3) in lym- phocytes has been recently implicated in the regulation of Fas-induced programmed cell death. Here, we demonstrate that ceramide, a lipid metabolite synthesized upon Fas receptor ligation, inhibits n-K~+ channel activity and induces a tyrosine phosphorylation of the Kv1.3 protein in Jurkat T lymphocytes. Tyrosine phosphorylation of the n-K~+ channel correlated with an activation of the Src-like tyrosine kinase p56lck upon cellular treatment with the ceramide analog C6-ceramide.

机译：淋巴细胞中的n型K〜+通道（n-K〜+，Kv1.3）最近与Fas诱导的程序性细胞死亡的调控有关。在这里，我们证明神经酰胺，一种Fas受体连接后合成的脂质代谢产物，抑制n-K〜+通道活性并诱导Jurkat T淋巴细胞中Kv1.3蛋白的酪氨酸磷酸化。用神经酰胺类似物C6-神经酰胺进行细胞处理后，n-K〜+通道的酪氨酸磷酸化与Src样酪氨酸激酶p56lck的激活有关。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第14期|p.7661-7666|共6页
作者
Erich Gulbins; Ildiko Szabo; Katharina Baltzer;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Modulation of K_V1.3 channels by protein kinase A I in T lymphocytes is mediated by the disc large 1-tyrosine kinase Lck complex [J] . Zerrin Kuras, Vladimir Kucher, Scott M. Gordon, American Journal of Physiology . 2012,第5aPta1期

机译：通过蛋白激酶A I在T淋巴细胞中的k_v1.3通道的调节由圆盘大1-酪氨酸激酶LCK复合物介导
2. Phosphorylation-dependent and phosphorylation-independent modes of modulation of shaker family voltage-gated potassium channels by SRC family protein tyrosine kinases. [J] . Nitabach MN, Llamas DA, Thompson IJ, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2002,第18期

机译：SRC家族蛋白酪氨酸激酶调节振动子家族电压门控钾通道的磷酸化依赖性和磷酸化依赖性模式。
3. Functional Blockade of the Voltage-gated Potassium Channel Kv1.3 Mediates Reversion of T Effector to Central Memory Lymphocytes through SMAD3/p21cip1 Signaling [J] . Lina Hu, Anne R. Gocke, Edward Knapp, The Journal of biological chemistry . 2012,第2期

机译：电压门控钾通道Kv1.3通过Smad3 / P21cip1信号传导介导T效应器的逆转T效应子的逆转
4. HERG POTASSIUM CHANNEL IS REGULATED BY PROTEIN TYROSINE KINASE (PTK) IN HUMAN EMBRYONIC KIDNEYCELLS [C] . LONG-MEI W International Congress on Electrocardiology . 2005

机译：Herg Potassium通道受蛋白酪氨酸激酶（PTK）调节人胚胎肾脏细胞
5. The role of tyrosine kinases and calcineurin in the calcium-mediated modulation of the voltage-gated potassium channel, Kv1.1. [D] . Hallahan, Brent J. 2006

机译：酪氨酸激酶和钙调磷酸酶在钙介导的电压门控钾通道Kv1.1的调节中的作用。
6. Ceramide-induced inhibition of T lymphocyte voltage-gated potassium channel is mediated by tyrosine kinases [O] . Erich Gulbins, Ildiko Szabo, Katharina Baltzer, 1997

机译：神经酰胺诱导的酪氨酸激酶介导的对T淋巴细胞电压门控钾通道的抑制
7. Functional blockade of the voltage-gated potassium channel Kv1.3 mediates reversion of T effector to central memory lymphocytes through SMAD3/p21 cip1 signaling [O] . Hu, Lina, Calabresi, Peter A., Whartenby, Katharine A., 2012

机译：电压门控钾通道Kv1.3的功能性阻断通过smaD3 / p21 cip1信号通路介导T效应器向中枢记忆淋巴细胞的逆转

Ceramide-induced inhibition of T lymphocyte voltage-gated potassium channel is mediated by tyrosine kinases

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