Interaction of human apurinic endonuclease and DNA polymerase β in the base excision repair pathway

Richard A. O. Bennett; David M. Wilson III; Donny Wong

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Interaction of human apurinic endonuclease and DNA polymerase β in the base excision repair pathway

机译：人嘌呤内切核酸酶和DNA聚合酶β在碱基切除修复途径中的相互作用

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Mutagenic abasic (AP) sites are generated directly by DNA-damaging agents or by DNA glycosylases acting in base excision repair. AP sites are corrected via incision by AP endonucleases, removal of deoxyribose 5-phos- phate, repair synthesis, and ligation. Mammalian DNA poly- merase β (Polβ) carries out most base excision repair syn- thesis and also can excise deoxyribose 5-phosphate after AP endonuclease incision. Yeast two-hybrid analysis now indi- cates protein-protein contact between Polβ and human AP endonuclease (Ape protein).

机译：诱变性脱碱基（AP）位点直接由破坏DNA的试剂或在碱基切除修复中起作用的DNA糖基化酶直接产生。通过切割AP内切核酸酶，去除磷酸5磷酸脱氧核糖，修复合成和连接来校正AP位点。哺乳动物DNA聚合酶β（Polβ）执行大多数碱基切除修复合成，并且在AP核酸内切酶切开后还可以切除5-磷酸脱氧核糖。现在，酵母双杂交分析表明Polβ和人类AP核酸内切酶（Ape蛋白）之间存在蛋白质-蛋白质接触。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第14期|p.7166-7169|共4页
作者
Richard A. O. Bennett; David M. Wilson III; Donny Wong;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Human base excision repair enzymes apurinic/apyrimidinic endonuclease1 (APE1), DNA polymerase beta and poly(ADP-ribose) polymerase 1: interplay between strand-displacement DNA synthesis and proofreading exonuclease activity [J] . Sukhanova MV, Khodyreva SN, Lebedeva NA, Nucleic Acids Research . 2005,第4期

机译：人类碱基切除修复酶嘌呤/嘧啶核糖核酸内切酶1（APE1），DNA聚合酶β和聚（ADP-核糖）聚合酶1：链置换DNA合成与校对核酸外切酶活性之间的相互作用
2. Human base excision repair enzymes apurinic/apyrimidinic endonuclease1 (APE1), DNA polymerase β and poly(ADP-ribose) polymerase 1: interplay between strand-displacement DNA synthesis and proofreading exonuclease activity [J] . Maria V. Sukhanova, Natalia A. Lebedeva, Olga I. Lavrik, Nucleic acids research . 2005,第4期

机译：人类碱基切除修复酶嘌呤/嘧啶核糖核酸内切酶1（APE1），DNA聚合酶β和聚（ADP-核糖）聚合酶1：链置换DNA合成与校对核酸外切酶活性之间的相互作用
3. The checkpoint clamp, Rad9-Rad1-Hus1 complex, preferentially stimulates the activity of apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta in long patch base excision repair [J] . Gembka A, Toueille M, Smirnova E, Nucleic Acids Research . 2007,第8期

机译：检查点钳位Rad9-Rad1-Hus1复合体可在长斑块碱基切除修复中优先刺激嘌呤/嘧啶内切核酸酶1和DNA聚合酶β的活性
4. Measurement of DNA Repair Protein Apurinic/Apyrimidinic Endonuclease 1 (APE1) in Human Tissues by Liquid Chromatography/Tandem Mass Spectrometry with Isotope Dilution [C] . Pawel Jaruga, Guldal Kirkali, Prasad T. Reddy, ASMS Conference on Mass Spectrometry and Allied Topics . 2016

机译：用同位素稀释测量人体组织中DNA修复蛋白茴香蛋白/亚氨基酰胺内核酸酶1（APE1），同位素稀释
5. Coordination of the Initial Steps of Base Excision Repair: Characterizing Apurinic/apyrimidinic Endonuclease 1 Stimulation of Thymine DNA Glycosylase [D] . Fitzgerald, Megan Elizabeth 2011

机译：碱基切除修复的初始步骤的协调：表征胸腺嘧啶脱氧核糖核酸糖基化酶的apurinic / apyrimidinic核酸内切酶1的刺激。
6. Interaction of human apurinic endonuclease and DNA polymerase β in the base excision repair pathway [O] . Richard A. O. Bennett, David M. Wilson III, Donny Wong, 1997

机译：人嘌呤核酸内切酶与DNA聚合酶β在碱基切除修复途径中的相互作用
7. Interaction of human apurinic endonuclease and DNA polymerase in the base excision repair pathway [O] . R. A. O. Bennett, D. M. Wilson, D. Wong, 1997

机译：人暂性内切核酸酶和DNA聚合酶在基础切除修复途径中的相互作用

Interaction of human apurinic endonuclease and DNA polymerase β in the base excision repair pathway

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