Reduced fertility in mice deficient for the POU protein sperm-1

Richard V. Pearse II; Daniel W. Drolet; Kristin A. Kalla

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Reduced fertility in mice deficient for the POU protein sperm-1

机译：缺乏POU蛋白sperm-1的小鼠的生育力降低

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Members of the POU-homeodomain gene family encode transcriptional regulatory molecules that play important roles in terminal differentiation of many organ systems. Sperm-1 (Sprm-1) is a POU domain factor that is exclusively expressed in the differentiating male germ cell. We show here that the Sprm-1 protein is expressed in the haploid spermatid and that 129/Sv Sprm-1(-/-) mice are subfertile when compared with wild-type or heterozygous littermates yet exhibit normal testicular morphology and produce normal numbers of mobile spermatozoa. Our data suggest that the Sprm-1 protein plays a discrete regulatory function in the haploid spermatid, which is required for the optimal function, but not the terminal differentiation, of the male germ cell.

机译：POU-同源结构域基因家族的成员编码在许多器官系统的终末分化中起重要作用的转录调节分子。精子1（Sprm-1）是一个POU域因子，仅在分化的雄性生殖细胞中表达。我们在这里显示，Sprm-1蛋白在单倍体精子细胞中表达，与野生型或杂合同窝仔相比，129 / Sv Sprm-1（-/-）小鼠可育，但它们表现出正常的睾丸形态并产生正常数量的移动精子。我们的数据表明，Sprm-1蛋白在单倍体精子细胞中具有离散的调节功能，这是雄性生殖细胞的最佳功能而非终末分化所必需的。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第14期|p.7555-7560|共6页
作者
Richard V. Pearse II; Daniel W. Drolet; Kristin A. Kalla;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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机译：小鼠缺乏卵母细胞特异的寡聚腺苷酸合成酶样蛋白OAS1D显示降低的生育力
2. Mice Deficient for Testis-Brain RNA-Binding Protein Exhibit a Coordinate Loss of TRAX, Reduced Fertility, Altered Gene Expression in the Brain, and Behavioral Changes [J] . Vargheese Chennathukuzhi, Joel M. Stein, Ted Abel, Molecular and Cellular Biology . 2003,第18期

机译：睾丸-大脑RNA结合蛋白不足的小鼠表现出TRAX坐标丢失，生育力降低，脑中基因表达改变和行为改变。
3. Impaired ovarian development and reduced fertility in female mice deficient in Skp2. [J] . Fotovati A, Abu Ali S, Nakayama K, Journal of Anatomy . 2011,第6期

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4. Quantitative Analysis of Brain Synaptic Plasma Membrane Proteins from DHA-Deficient and Adequate Mice Using ~(16)O/~(18)O Labeling [C] . Vishaldeep K. Sidhu, Bill Huang, Hee-Yong Kim American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：使用〜（16）o /〜（18）o标记从DHA缺陷和足够小鼠中脑突触血浆膜蛋白的定量分析
5. Natural killer cells from mice deficient in protein kinase C-theta have reduced production of interferon-gamma after stimulation with interleukin-12. [D] . Bourque, Karen Michelle. 2007

机译：来自蛋白激酶C-θ缺陷的小鼠的自然杀伤细胞在白介素12刺激后降低了干扰素-γ的产生。
6. Reduced fertility in mice deficient for the POU protein sperm-1 [O] . Richard V. Pearse II, Daniel W. Drolet, Kristin A. Kalla, 1997

机译：缺乏POU蛋白sperm-1的小鼠的生育力降低
7. Mice Deficient in Oocyte-Specific Oligoadenylate Synthetase-Like Protein OAS1D Display Reduced Fertility† [O] . Yan, Wei, Ma, Lang, Stein, Paula, 2005

机译：卵母细胞特异的寡聚腺苷酸合成酶样蛋白OAS1D缺乏的小鼠生育力降低†

Reduced fertility in mice deficient for the POU protein sperm-1

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