...
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Cloning of a gene (RIG-G) associated with retinoic acid-induced differentiation of acute promyelocytic leukemia cells and representing a new member of a family of interferon- stimulated genes
【24h】

Cloning of a gene (RIG-G) associated with retinoic acid-induced differentiation of acute promyelocytic leukemia cells and representing a new member of a family of interferon- stimulated genes

机译:与视黄酸诱导的急性早幼粒细胞白血病细胞分化相关的基因(RIG-G)的克隆,代表干扰素刺激基因家族的新成员

获取原文
获取原文并翻译 | 示例
           

摘要

In a cell line (NB4) derived from a patient with acute promyelocytic leukemia, all-trans-retinoic acid (ATRA) and interferon (IFN) induce the expression of a novel gene we call RIG-G (for retinoic acid-induced gene G). This gene codes for a 58-kDa protein containing 490 amino acids with several potential sites for post-translational modifica- tion. In untreated NB4 cells, the expression of RIG-G is undetectable. ATRA treatment induces the transcriptional expression of RIG-G relatively late (12-24 hr) in a protein synthesis-dependent manner, whereas IFN-α induces its ex- pression early (30 min to 3 hr).
机译:在源自急性早幼粒细胞白血病患者的细胞系(NB4)中,全反式维甲酸(ATRA)和干扰素(IFN)诱导表达新基因的表达,我们称之为RIG-G(对于维甲酸诱导的基因G )。该基因编码一个含有490个氨基酸的58 kDa蛋白,具有几个潜在的翻译后修饰位点。在未经处理的NB4细胞中,RIG-G的表达无法检测到。 ATRA处理以蛋白质合成依赖性方式相对较晚(12-24小时)诱导RIG-G的转录表达,而IFN-α则较早(30分钟至3小时)诱导其表达。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号