Chemical camouflage of antigenic determinants: Stealth erythrocytes

Mark D. Scott; Kari L. Murad; Fotios Koumpouras

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Chemical camouflage of antigenic determinants: Stealth erythrocytes

机译：抗原决定簇的化学伪装：隐身红细胞

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In a number of clinical circumstances it would be desirable to artificially conceal cellular antigenic determinants to permit survival of heterologous donor cells. A case in point is the problem encountered in transfusions of patients with rare blood types or chronically transfused patients who become allosensitized to minor blood group determinants. We have tested the possibility that chemical modification of the red blood cell (RBC) membrane might serve to occlude antigenic determinants, thereby minimizing transfusion reactions. To this end, we have covalently bound methoxy(polyethylene glycol) (mPEG) to the surface of mam- malian RBC via cyanuric chloride coupling.

机译：在许多临床情况下，理想的是人工隐藏细胞抗原决定簇以允许异源供体细胞存活。一个典型的例子是在输注稀有血型的患者或对次要血型决定簇变得同化的慢性输血患者中遇到的问题。我们已经测试了红细胞（RBC）膜的化学修饰可能会阻塞抗原决定簇的可能性，从而最大程度地减少了输血反应。为此，我们已经通过氰尿酰氯偶联将甲氧基（聚乙二醇）（mPEG）共价结合到哺乳动物红细胞的表面。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第14期|p.7566-7571|共6页
作者
Mark D. Scott; Kari L. Murad; Fotios Koumpouras;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Chemical camouflage of nanospheres with a poorly reactive surface: towards development of stealth and target-specific nanocarriers. [J] . Moghimi SM Biochimica et biophysica acta: international journal of biochemistry and biophysics . 2002,第1a3期

机译：具有不良反应性的纳米球的化学伪装：向隐身和目标特定的纳米载体发展。
2. Chemical camouflage of nanospheres with a poorly reactive surface: towards development of stealth and target-specific nanocarriers [J] . S. M. Moghimi Biochimica et biophysica acta. Molecular cell research . 2002,第1a3期

机译：具有不良反应性的纳米球的化学伪装：向隐身和目标特定的纳米载体发展
3. Crystal and Solution Structures of Plasmodium falciparum Erythrocyte-binding Antigen 140 Reveal Determinants of Receptor Specificity during Erythrocyte Invasion [J] . Daniel Lin, Brian Malpede, Joseph Batchelor, The Journal of biological chemistry . 2012,第44期

机译：疟原虫红细胞结合抗原140的晶体和溶液结构揭示了红细胞侵袭期间受体特异性的决定因素
4. 3D simulation of a sensorimotor stealth strategy for camouflaging motion [C] . Anderson, A.J., McOwan, . 2002

机译：伪装运动的感觉运动隐身策略的3D仿真
5. IMMUNE CAPABILITIES OF THE ZEBRAFISH, BRACHYDANIO RERIO (HAMILTON-BUCHANAN): I. IMMUNE RESPONSE TO VIRAL, ERYTHROCYTE AND BACTERIAL ANTIGENS. II. EFFECT OF SUBLETHAL DOSES OF ZINC ON THE IMMUNERESPONSE TO VIRAL AND BACTERIAL ANTIGENS. [D] . SAROT, DANIEL ARTHUR. 1973

机译：斑马鱼，布拉迪达尼奥·雷里奥（HAMILTON-BUCHANAN）的免疫能力：I.对病毒，红细胞和细菌抗原的免疫反应。二。锌的剂量对病毒和细菌抗原的免疫反应的影响。
6. Chemical camouflage of antigenic determinants: Stealth erythrocytes [O] . Mark D. Scott, Kari L. Murad, Fotios Koumpouras, 1997

机译：抗原决定簇的化学伪装：隐形红细胞
7. Chemical camouflage of nanospheres with a poorly reactive surface: towards development of stealth and target-specific nanocarriers [O] . Moghimi, S.M. 2002

机译：具有不良反应性的纳米球的化学伪装：向隐身和目标特定的纳米载体发展
8. RESEARCH ON THE PRODUCTION AND IMMUNOLOGICAL EXAMINATION OF ARTIFICIAL ANTIGENS CONTAINING KNOWN SUGARS (OR OLIGO-SACCARIDES) AS THE DETERMINANT GROUPS, IN RELATION TO THE IMMUNOCHEMICAL ANALYSIS OF ENTEROBACTERIAL O-ANTI-GENS (ENDOTOXINS) [R] . Otto Westphal 1963

机译：含有已知糖（或寡糖）的人工抗原作为决定团体的生产和免疫检测的研究，与对抗细菌O-抗原（内毒素）的免疫化学分析有关

Chemical camouflage of antigenic determinants: Stealth erythrocytes

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