Characterization of tumor necrosis factor-deficient mice

Michael W. Marino; Ashley Dunn; Dianne Grail

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Characterization of tumor necrosis factor-deficient mice

机译：肿瘤坏死因子缺乏小鼠的表征

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Although tumor necrosis factor (TNF) initially came to prominence because of its anti-tumor activity, most attention is now focused on its proinflammatory actions. TNF appears to play a critical role in both early and late events involved in inflammation, from localizing the noxious agent and amplifying the cellular and mediator responses at the local site and systemically, to editing (e.g., apoptosis) injured cells or effete immune cells and repairing inflammatory damage. We have generated mice deficient in TNF (TNF~-/- mice) and have begun to examine the multiple functions attributed to TNF. TNF~-/- mice develop normally and have no gross structural or morpho- logical abnormalities.

机译：尽管肿瘤坏死因子（TNF）由于其抗肿瘤活性而开始引起人们的关注，但现在大多数注意力都集中在其促炎作用上。 TNF在涉及炎症的早期和晚期事件中似乎都起着至关重要的作用，从定位有毒物质并在局部和全身放大细胞和介导的反应，到编辑（例如凋亡）受伤的细胞或有效的免疫细胞以及修复炎症损伤。我们已经产生了TNF缺乏的小鼠（TNF-/-小鼠），并且已经开始研究归因于TNF的多种功能。 TNF-//-小鼠正常发育，没有明显的结构或形态异常。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第15期|p.8093-8098|共6页
作者
Michael W. Marino; Ashley Dunn; Dianne Grail;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Beneficial Dysregulation of the Time Course of Inflammatory Mediators in Lipopolysaccharide-Induced Tumor Necrosis Factor Alpha Factor-Deficient Mice [J] . Sreedevi Srinivasan, Susan E. Leeman, Salomon Amar Clinical and vaccine immunology: CVI . 2010,第5期

机译：脂多糖诱导的肿瘤坏死因子α因子缺陷型小鼠炎症介导的时间进程的有益失调。
2. Stromal cell strains derived from suspension fraction of bone marrow cultures of tumor necrosis factor-deficient mice. [J] . Nifontova IN, Olshanskaya YV, Drize NI Bulletin of experimental biology and medicine . 2004,第3期

机译：基质细胞株衍生自肿瘤坏死因子缺乏小鼠的骨髓培养物的悬浮液部分。
3. Long-term self-maintenance of hemopoietic precursors in bone marrow culture derived from tumor necrosis factor-deficient mice is not a result of neoplastic transformation. [J] . Ershler MA lood.ru, Nifontova IN, Olshanskaya YV, Bulletin of experimental biology and medicine . 2002,第5期

机译：源自肿瘤坏死因子缺乏小鼠的骨髓培养物中造血前体的长期自我维持不是肿瘤转化的结果。
4. Melphalan Reduces the Severity of Experimental Colitis in Mice by Blocking Tumor Necrosis Factor-α Signaling Pathway [C] . GALINA SHMARINA, ALEXANDER PUKHALSKY, VLADIMIR ALIOSHKIN, Meeting on Cell Signaling World: Signal Transduction Pathways as Therapeutic Targets . 2007

机译：美法仑通过阻断肿瘤坏死因子-α信号通路降低小鼠实验性结肠炎的严重性
5. Characterization and genetic analysis of the resistance of nonobese diabetic mice to tumor necrosis factor-alpha-mediated hepatocyte apoptosis and lethality. [D] . Bahjat, Frances Rena. 2002

机译：非肥胖糖尿病小鼠对肿瘤坏死因子-α介导的肝细胞凋亡和致死性的抗性表征和遗传分析。
6. Characterization of tumor necrosis factor-deficient mice [O] . Michael W. Marino, Ashley Dunn, Dianne Grail, 1997

机译：肿瘤坏死因子缺乏症小鼠的特征
7. Characterization of tumor necrosis factor-deficient mice [O] . M. W. Marino, A. Dunn, D. Grail, 1997

机译：肿瘤坏死因子缺陷小鼠的表征
8. Pretreatment with Recombinant Murine Tumor Necrosis Factor Alpha/Cachectin and Murine Interleukin 1 Alpha Protects Mice from Lethal Bacterial Infection. [R] . Cross, A. S., Sadoff, J. C., Kelly, N., 1989

机译：用重组小鼠肿瘤坏死因子α/ Cachectin和小鼠白细胞介素1α预处理使小鼠免于致死性细菌感染。

Characterization of tumor necrosis factor-deficient mice

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