Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(α1*0101,β 1*0401) transgenic mice

Salil D. Patel; Andrew P. Cope; Mauro Congia

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Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(α10101,β 10401) transgenic mice

机译：用HLA-DR（α1* 0101，β1 * 0401）转基因小鼠鉴定人谷氨酸脱羧酶65的免疫T细胞抗原决定簇

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Glutamic acid decarboxylase isoform 2 (GAD65; EC 4.1.1.15) has been identified as a key target autoantigen of insulin-dependent diabetes mellitus (IDDM). IDDM is genetically associated with the major histocompat- ibility complex (MHC), and particular alleles from the HLA-DQ and HLA-DR loci contribute to disease. Among DR4 subtypes, HLA-DRB1*0401, HLA-DRB1*0402, and HLA- DRB1*0405 alleles lend susceptibility, while HLA-DRB1*0403 confers protection. We have utilized HLA-DR(α1*0101, β1*0401) (hereafter referred to as DR0401), human CD4, murine class II null triple transgenic mice and recombinant GAD65 to generate T cell hybridomas, and we have used overlapping sets of peptides to map the immunodominant epitopes of this autoantigen.

机译：谷氨酸脱羧酶同工型2（GAD65; EC 4.1.1.15）已被确定为胰岛素依赖型糖尿病（IDDM）的关键靶标自身抗原。 IDDM与主要的组织相容性复合体（MHC）在遗传上相关，并且HLA-DQ和HLA-DR基因座的特定等位基因会导致疾病。在DR4亚型中，HLA-DRB1 * 0401，HLA-DRB1 * 0402和HLA-DRB1 * 0405等位基因具有敏感性，而HLA-DRB1 * 0403具有保护作用。我们已经利用HLA-DR（α1* 0101，β1* 0401）（以下简称DR0401），人类CD4，鼠II类无效三联转基因小鼠和重组GAD65产生T细胞杂交瘤，并且我们使用了重叠的肽组绘制该自身抗原的免疫显性表位。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第15期|p.8082-8087|共6页
作者
Salil D. Patel; Andrew P. Cope; Mauro Congia;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Differential presentation of glutamic acid decarboxylase 65 (GAD65) T cell epitopes among HLA-DRB1*0401-positive individuals. [J] . Reijonen H, Elliott JF, van Endert-P, The Journal of Immunology: Official Journal of the American Association of Immunologists . 1999,第3期

机译：HLA-DRB1 * 0401阳性个体中谷氨酸脱羧酶65（GAD65）T细胞表位的差异表达。
2. Differential Presentation of Glutamic Acid Decarboxylase 65 (GAD65) T Cell Epitopes Among HLA-DRB1*0401-Positive Individuals [J] . Helena Reijonen, John F. Elliott, Peter van Endert, The journal of immunology . 1999,第3期

机译：HLA-DRB1 * 0401阳性个体中谷氨酸脱羧酶65（GAD65）T细胞表位的差异表达
3. Identification and modulation of a naturally processed T cell epitope from the diabetes- associated autoantigen human glutamic acid decarboxylase 65 (hGAD65) [J] . Gerald T. Nepom, John D. Lippolis, Forest M. White Proceedings of the National Academy of Sciences of the United States of America . 2001,第4期

机译：从糖尿病相关的自身抗原人类谷氨酸脱羧酶65（hGAD65）鉴定和调节天然加工的T细胞表位
4. Evaluation of HTL V-1 cytotoxic T-cell epitopes in HLA-A2.1 transgenic mice [C] . Roshni Sundaram, Christopher MWalker, Pravin T.P.Kaumaya the International Peptide Symposium . 2001

机译：HLA-A2.1转基因小鼠HTL V-1细胞毒性T细胞表位的评价
5. Molecular and structural characterization of autoreactive epitopes in human glutamic acid decarboxylase (GAD 65). [D] . Schwartz, Heather Lauren. 1998

机译：人谷氨酸脱羧酶（GAD 65）中自身反应性表位的分子和结构表征。
6. Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(α1*0101β1*0401) transgenic mice [O] . Salil D. Patel, Andrew P. Cope, Mauro Congia, 1997

机译：用HLA-DR（α1* 0101β1* 0401）转基因小鼠鉴定人谷氨酸脱羧酶65的免疫性T细胞抗原决定簇
7. Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401. [O] . Wicker, L S, Chen, S L, Nepom, G T, 1996

机译：使用与1型糖尿病相关的人类MHC II类等位基因DRB1 * 0401转基因的小鼠，从人谷氨酸脱羧酶天然加工的T细胞抗原决定簇。

Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(α1*0101,β 1*0401) transgenic mice

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Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(α10101,β 10401) transgenic mice