Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination

Yansong Gu; Shengfang Jin; Yijie Gao

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Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination

机译：Ku70缺陷的胚胎干细胞具有更高的电离放射敏感性，缺陷的DNA末端结合活性以及无法支持V（D）J重组

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V(D)J recombination requires both lym- phoid-specific and generally expressed enzymatic activities. All three known generally expressed activities involved in V(D)J recombination are also involved in DNA double-strand break repair (DSBR). Two of these are components of the DNA-dependent protein kinase (DNA-PK) and include Ku80 and DNA-PK catalytic subunit (DNA-PKcs); the third, XRCC4, is a protein of unknown function. The Ku70 protein is an additional component of DNA-PK; Ku70 forms a het- erodimer with Ku80 to generate the DNA end-binding com- ponent of the enzyme.

机译：V（D）J重组需要淋巴特异性和一般表达的酶活性。与V（D）J重组有关的所有三个已知的普遍表达的活性也与DNA双链断裂修复（DSBR）有关。其中两个是DNA依赖性蛋白激酶（DNA-PK）的组成部分，包括Ku80和DNA-PK催化亚基（DNA-PKcs）。第三个是XRCC4，是功能未知的蛋白质。 Ku70蛋白是DNA-PK的另一个组成部分。 Ku70与Ku80形成异源二聚体，以生成该酶的DNA末端结合成分。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第15期|p.8076-8081|共6页
作者
Yansong Gu; Shengfang Jin; Yijie Gao;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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4. Effects of increased telomerase activity on radiosensitive human SCID cells [C] . Yoshiko Arase, Katsuo Sugit, Takaki Hiwasab International Symposium of Radiation and Homeostasis . 2002

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5. Double-strand DNA break repair by homologous recombination contributes to the preservation of genomic stability in mouse embryonic stem cells. [D] . Tichy, Elisia D. 2010

机译：通过同源重组的双链DNA断裂修复有助于维持小鼠胚胎干细胞的基因组稳定性。
6. Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity defective DNA end-binding activity and inability to support V(D)J recombination [O] . Yansong Gu, Shengfang Jin, Yijie Gao, 1997

机译：Ku70缺陷的胚胎干细胞具有增加的电离放射敏感性有缺陷的DNA末端结合活性以及无法支持V（D）J重组
7. Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination [O] . Y. Gu, S. Jin, Y. Gao, 1997

机译：Ku70缺乏胚胎干细胞具有增加的电离放射敏感性，缺陷的DNA末端结合活性，无法支持V（D）J重组

Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination

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