Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: Induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal

Laura E. Benjamin; Eli Keshet

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Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: Induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal

机译：肿瘤中血管内皮生长因子（VEGF）表达的条件转换：VEGF撤药诱导内皮细胞脱落和血管母细胞瘤样血管消退

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We have recently shown that VEGF functions as a survival factor for newly formed vessels during develop- mental neovascularization, but is not required for mainte- nance of mature vessels. Reasoning that expanding tumors contain a significant fraction of newly formed and remodeling vessels, we examined whether abrupt withdrawal of VEGF will result in regression of preformed tumor vessels. Using a tetracycline-regulated VEGF expression system in xe- nografted C6 glioma cells, we showed that shutting off VEGF production leads to detachment of endothelial cells from the walls of preformed vessels and their subsequent death by apoptosis.

机译：我们最近发现，在发育性新血管形成过程中，VEGF可以作为新生血管的生存因子，但对成熟血管的维护并不是必需的。鉴于不断膨胀的肿瘤中包含大量新形成和重塑的血管，我们检查了VEGF的突然撤除是否会导致预先形成的肿瘤血管消退。在异种移植的C6胶质瘤细胞中使用四环素调节的VEGF表达系统，我们显示，关闭VEGF的产生可导致内皮细胞从预制血管壁脱离，并随后通过凋亡而死亡。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第16期|p.8761-8766|共6页
作者
Laura E. Benjamin; Eli Keshet;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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4. ~(123)I-Vascular Endothelial Growth Factor165 (~(123)I-VEGF_(165)) Binding Sites in Tumor Cells: Implication for Tumor Scintigraphy [C] . S.R. Li, C. Bischof, S. Kapiotis, NATO Advanced Study Institute on Vascular Endothelium : Mechanisms of Cell Signaling . 1999

机译：〜（123）I-血管内皮生长因子165（〜（123）I-VEGF_（165））肿瘤细胞中的结合位点：肿瘤闪烁的含义
5. Strategies in anti-angiogenic cancer therapy: Exploiting the role of vascular endothelial growth factor (VEGF) in tumor growth and endothelial cell survival. [D] . Wild, Robert Christian. 2000

机译：抗血管生成癌治疗的策略：利用血管内皮生长因子（VEGF）在肿瘤生长和内皮细胞存活中的作用。
6. Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: Induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal [O] . Laura E. Benjamin, Eli Keshet 1997

机译：肿瘤中血管内皮生长因子（VEGF）表达的条件转换：VEGF的诱导诱导内皮细胞脱落和血管母细胞瘤样血管的消退
7. Ultrastructural Localization of the Vascular Permeability Factor/Vascular Endothelial Growth Factor (VPF/VEGF) Receptor-2 (FLK-1, KDR) in Normal Mouse Kidney and in the Hyperpermeable Vessels Induced by VPF/VEGF-expressing Tumors and Adenoviral Vectors [O] . Dian Feng, Janice A. Nagy, Rolf A. Brekken, 2000

机译：血管渗透性因子/血管内皮生长因子（VPF / VEGF）受体-2（FLK-1，KDR）的超微结构定位在正常小鼠肾癌中，并在VPF / VEGF表达肿瘤和腺病毒载体诱导的高耐血管血管中

Conditional switching of vascular endothelial growth factor (VEGF) expression in tumors: Induction of endothelial cell shedding and regression of hemangioblastoma-like vessels by VEGF withdrawal

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