Translational coupling by modulation of feedback repression in the IF3 operon of Escherichia coli

C. Chiaruttini; M. Milet; M. Springer

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Translational coupling by modulation of feedback repression in the IF3 operon of Escherichia coli

机译：通过调节大肠杆菌IF3操纵子中反馈抑制的翻译偶联

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A pseudoknot formed by a long-range inter- action in the mRNA of the initiation factor 3 (IF3) operon is involved in the translational repression of the gene encoding ribosomal protein L35 by another ribosomal protein, L20. The nucleotides forming the 5 strand of the key stem of the pseudoknot are located within the gene for IF3, whereas those forming the 3' strand are located 280 nt downstream, imme- diately upstream of the Shine-Dalgarno sequence of the gene for L35. Here we show that premature termination of IF3 translation at a nonsense codon introduced upstream of the pseudoknot results in a substantial enhancement of L20- mediated repression of L35 expression.

机译：由起始因子3（IF3）操纵子的mRNA的长距离相互作用形成的假结参与编码核糖体蛋白L35的基因被另一种核糖体蛋白L20的翻译抑制。形成假结关键茎5链的核苷酸位于IF3基因内，而形成3'链的核苷酸位于L35基因Shine-Dalgarno序列的下游280 nt，紧邻上游。在这里，我们显示在假结上游引入的无意义密码子处IF3翻译的过早终止导致L20介导的L35表达抑制的显着增强。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第17期|p.9208-9213|共6页
作者
C. Chiaruttini; M. Milet; M. Springer;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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正文语种 eng
中图分类自然科学总论;
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1. Feedback regulation of the spc operon in Escherichia coli: translational coupling and mRNA processing. [J] . L C Mattheakis, M Nomura Journal of bacteriology . 1988,第10期

机译：大肠杆菌中spc操纵子的反馈调控：翻译偶联和mRNA加工。
2. Restoration of a translational stop-start overlap reinstates translational coupling in a mutant trpB′-trpA gene pair of the Escherichia coli tryptophan operon [J] . Anath Das, Charles Yanofsky Nucleic acids research . 1989,第22期

机译：翻译停止-起始重叠的恢复恢复了大肠杆菌色氨酸操纵子的突变trpB'-trpA基因对中的翻译偶联。
3. Restoration of a translational stop-start overlap reinstates translational coupling in a mutant trpB′-trpA gene pair of the Escherichia coli tryptophan operon [J] . Anath Das, Charles Yanofsky Nucleic acids research . 1989,第22期

机译：翻译停止-起始重叠的恢复恢复了大肠杆菌色氨酸操纵子的突变trpB'-trpA基因对中的翻译偶联。
4. Temperature Dependence of Leakiness of Transcription Repression Mechanisms of Escherichia coli [C] . Nadia Goncalves, Samuel M.D. Oliveira, Vinodh K. Kandavalli, International conference on computational methods in systems biology . 2016

机译：大肠杆菌转录抑制机制的渗漏温度依赖性
5. ANALYSIS OF THE DYNAMIC BEHAVIOR OF THE TRYPTOPHAN OPERON OF ESCHERICHIA COLI: THE FUNCTIONAL SIGNIFICANCE OF FEEDBACK INHIBITION. [D] . BLISS, RICHARD DEXTER. 1979

机译：大肠埃希氏菌Tryptophan operron的动力学行为分析：反馈抑制的功能意义。
6. Translational coupling by modulation of feedback repression in the IF3 operon of Escherichia coli [O] . C. Chiaruttini, M. Milet, M. Springer 1997

机译：通过调节大肠杆菌IF3操纵子中反馈抑制的平移耦合
7. Feedback regulation of the spc operon in Escherichia coli: translational coupling and mRNA processing. [O] . Mattheakis, L C, Nomura, M 1988

机译：大肠杆菌中spc操纵子的反馈调控：翻译偶联和mRNA加工。

Translational coupling by modulation of feedback repression in the IF3 operon of Escherichia coli

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