A substance P (neurokinin-1) receptor mutant carboxyl-terminally truncated to resemble a naturally occurring receptor isoform displays enhanced responsiveness and resistance to desensitization

Hanzhong Li; Susan E. Leeman; Barbara E. Slack

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >A substance P (neurokinin-1) receptor mutant carboxyl-terminally truncated to resemble a naturally occurring receptor isoform displays enhanced responsiveness and resistance to desensitization

【24h】

A substance P (neurokinin-1) receptor mutant carboxyl-terminally truncated to resemble a naturally occurring receptor isoform displays enhanced responsiveness and resistance to desensitization

机译：羧基末端被截短以类似于天然受体同工型的P（神经激肽-1）受体突变体表现出增强的响应能力和对脱敏的抵抗力

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Two isoforms of the substance P (SP) recep- tor, differing in the length of the cytoplasmic carboxyl- terminus by ≈8 kDa, have been detected previously in rat salivary glands and other tissues. The binding and functional properties of these two isoforms have been investigated using full-length (407 amino acids) and carboxyl-terminally trun- cated (324 amino acids) rat SP receptors transfected stably into Chinese hamster ovary cells. Both the full-length and the truncated receptor bound radiolabeled SP with a similar Kd (≈0.1 nM). The average number of high affinity SP binding sites per cell was 1.0 * 10~5 and 0.3 * 10~5 for the full-length and the truncated SP receptor, respectively.

机译：先前已在大鼠唾液腺和其他组织中检测到了两种物质P（SP）受体的同工型，其胞质羧基末端的长度相差≈8kDa。已经使用稳定转染到中国仓鼠卵巢细胞中的全长（407个氨基酸）和羧基末端截短的（324个氨基酸）大鼠SP受体研究了这两种同工型的结合和功能特性。全长和截短的受体都以相似的Kd（≈0.1nM）结合放射性标记的SP。对于全长和截短的SP受体，每个细胞的高亲和力SP结合位点的平均数分别为1.0 * 10〜5和0.3 * 10〜5。

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第17期|p.9475-9480|共6页
作者
Hanzhong Li; Susan E. Leeman; Barbara E. Slack;
展开▼
作者单位

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词

相似文献

外文文献
中文文献
专利

1. Systematic expression analysis and antibody screening do not support the existence of naturally occurring progesterone receptor (PR)-C, PR-M, or other truncated PR isoforms. [J] . Samalecos A, Gellersen B Endocrinology . 2008,第11期

机译：系统表达分析和抗体筛选不支持天然存在的孕激素受体（PR）-C，PR-M或其他截短的PR同工型的存在。
2. Substance P (SP) enhances CCL5-induced chemotaxis and intracellular signaling in human monocytes, which express the truncated neurokinin-1 receptor (NK1R). [J] . Chernova I, Lai JP, Li H, Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society . 2009,第1期

机译：P物质（SP）增强人单核细胞中CCL5诱导的趋化性和细胞内信号传导，后者表达截短的Neurokinin-1受体（NK1R）。
3. Photoaffinity Labeling of Mutant neurokinin-1 Receptors Reveals Additional Structural Features of the Substance P/NK-1 Receptor Complex [J] . Douglas Macdonald, Dale F.Mierke, Hanzhong Li, Biochemistry . 2001,第8期

机译：突变体突变体的光谱附近标记揭示了物质P / NK-1受体复合物的额外结构特征
4. l-stepholidine, a naturally occurring dopamine D1 receptor agonist and D2 receptor antagonist, attenuates methamphetamine self-administration in rate [C] . Kai Yue, BaoMiao Ma, JunQiao Xing International Conference on Applied Sciences, Engineering and Technology . 2014

机译：L- StepHolidine，天然存在的多巴胺D1受体激动剂和D2受体拮抗剂，衰减甲基苯丙胺自我管理
5. Colonic epithelial genes in the transition from chronic inflammation to carcinoma in human colitis-associated cancer: Focus on the truncated neurokinin-1 receptor. [D] . Gillespie, Earl. 2013

机译：在人类结肠炎相关癌症中，从慢性炎症过渡到癌变过程中的结肠上皮基因：关注截短的神经激肽1受体。
6. A substance P (neurokinin-1) receptor mutant carboxyl-terminally truncated to resemble a naturally occurring receptor isoform displays enhanced responsiveness and resistance to desensitization [O] . Hanzhong Li, Susan E. Leeman, Barbara E. Slack, 1997

机译：羧基末端被截短以类似于天然受体同工型的P（神经激肽-1）受体突变体表现出增强的响应能力和对脱敏的抵抗力
7. Substance P (SP) enhances CCL5-induced chemotaxis and intracellular signaling in human monocytes, which express the truncated neurokinin-1 receptor (NK1R) [O] . Chernova, Irene, Lai, Jian-Ping, Li, Haiying, 2008

机译：P（SP）物质增强人单核细胞中CCL5诱导的趋化性和细胞内信号转导，其表达截短的神经激肽1受体（NK1R）

A substance P (neurokinin-1) receptor mutant carboxyl-terminally truncated to resemble a naturally occurring receptor isoform displays enhanced responsiveness and resistance to desensitization

摘要

著录项

相似文献

相关主题

期刊订阅