Antibodies to several conformation-dependent epitopes of gp120/gp41 inhibit CCR-5-dependent cell-to-cell fusion mediated by the native envelope glycoprotein of a primary macrophage-tropic HIV-1 isolate

Florence C. Verrier; Pierre Charneau; Ralf Altmeyer

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Antibodies to several conformation-dependent epitopes of gp120/gp41 inhibit CCR-5-dependent cell-to-cell fusion mediated by the native envelope glycoprotein of a primary macrophage-tropic HIV-1 isolate

机译：gp120 / gp41的几种构象依赖性表位的抗体可抑制CCR-5依赖性细胞间融合，该融合由一级巨噬细胞性HIV-1分离株的天然包膜糖蛋白介导。

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摘要

The β-chemokine receptor CCR-5 is essen- tial for the efficient entry of primary macrophage-tropic HIV-1 isolates into CD4~+ target cells. To study CCR-5- dependent cell-to-cell fusion, we have developed an assay system based on the infection of CD4~+ CCR-5~+ HeLa cells with a Semliki Forest virus recombinant expressing the gp120/gp41 envelope (Env) from a primary clade B HIV-1 isolate (BX08), or from a laboratory T cell line-adapted strain (LAI). In this system, gp120/gp41 of the "nonsyncytium- inducing," primary, macrophage-tropic HIV-1_BX08 isolate, was at least as fusogenic as that of the "syncytium-inducing" HIV-1_LAI strain.

机译：β趋化因子受体CCR-5对于有效地使嗜巨噬细胞原代HIV-1分离株有效进入CD4〜+靶细胞至关重要。为了研究依赖CCR-5的细胞间融合，我们开发了一种检测系统，该系统基于表达gp120 / gp41包膜（Env）的Semliki Forest病毒感染CD4〜+ CCR-5〜+ HeLa细胞来自主要进化枝B HIV-1分离株（BX08），或来自实验室T细胞系适应株（LAI）。在该系统中，“诱导非合胞体”的原代巨噬细胞型HIV-1_BX08分离株的gp120 / gp41与“诱导合胞子” HIV-1_LAI菌株的融合性至少相同。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第17期|p.9326-9331|共6页
作者
Florence C. Verrier; Pierre Charneau; Ralf Altmeyer;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Temperature-Dependent Intermediates in HIV-1 Envelope Glycoprotein-Mediated Fusion Revealed by Inhibitors that Target N- and C-Terminal Helical Regions of HIV-1 gp41 [J] . Stephen A.Gallo, G.Marius Clore, John M.Louis, Biochemistry . 2004,第25期

机译：依赖于HIV-1 gp41 N和C末端螺旋区的抑制剂揭示的HIV 1信封糖蛋白介导的融合中的温度依赖性中间体。
2. Potency of HIV-1 envelope glycoprotein gp120 antibodies to inhibit the interaction of DC-SIGN with HIV-1 gp120 [J] . Lekkerkerker AN, Ludwig IS, van Vliet SJ, Virology . 2004,第2期

机译：HIV-1包膜糖蛋白gp120抗体抑制DC-SIGN与HIV-1 gp120相互作用的效力
3. Expression and detection of macrophage-tropic HIV-1 gp120 in the brain using conformation-dependent antibodies. [J] . Altmeyer R, Mordelet E, Girard M, Virology . 1999,第2期

机译：使用构象依赖性抗体在大脑中表达和检测嗜巨噬细胞性HIV-1 gp120。
4. Antibodies to several conformation-dependent epitopes of gp120/gp41 inhibit CCR-5-dependent cell-to-cell fusion mediated by the native envelope glycoprotein of a primary macrophage-tropic HIV-1 isolate [O] . Florence C. Verrier, Pierre Charneau, Ralf Altmeyer, 1997

机译：gp120 / gp41的几种构象依赖性表位的抗体可抑制由巨噬细胞嗜性HIV-1β分离物的天然包膜糖蛋白介导的CCR-5依赖性细胞间融合。
5. Antibodies to several conformation-dependent epitopes of gp120/gp41 inhibit CCR-5-dependent cell-to-cell fusion mediated by the native envelope glycoprotein of a primary macrophage-tropic HIV-1 isolate [O] . F. C. Verrier, P. Charneau, R. Altmeyer, 1997

机译：对GP120 / GP41的几个构象依赖性表位的抗体抑制由原发性巨噬细胞 - 热性HIV-1分离物的天然包络糖蛋白介导的CCR-5依赖性细胞融合

Antibodies to several conformation-dependent epitopes of gp120/gp41 inhibit CCR-5-dependent cell-to-cell fusion mediated by the native envelope glycoprotein of a primary macrophage-tropic HIV-1 isolate

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