Endocrine modulation of the neurotoxicity of gp120: Implications for AIDS-related dementia complex

S. Brooke; R. Chan; S. Howard

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Endocrine modulation of the neurotoxicity of gp120: Implications for AIDS-related dementia complex

机译：gp120的神经毒性的内分泌调节：对艾滋病相关痴呆症的影响

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HIV infection often involves the development of AIDS-related dementia complex, a variety of neurologic, neuropsychologic, and neuropathologic impairments. A pos- sible contributor to AIDS-related dementia complex is the HIV envelope glycoprotein gp120, which damages neurons via a complex glutamate receptor- and calcium-dependent cas- cade. We demonstrate an endocrine modulation of the dele- terious effects of gp120 in primary hippocampal and cortical cultures. Specifically, we observe that gp120-induced calcium mobilization and neurotoxicity are exacerbated by glucocor- ticoids, the adrenal steroids secreted during stress.

机译：HIV感染通常涉及与AIDS有关的痴呆综合症，各种神经，神经心理和神经病理学损伤的发展。 HIV包膜糖蛋白gp120可能是与AIDS有关的痴呆综合症的病因，它通过复杂的谷氨酸受体和钙依赖性级联损伤神经元。我们证明了gp120在原代海马和皮层文化中的良好作用的内分泌调节。具体来说，我们观察到糖皮质激素加剧了gp120诱导的钙动员和神经毒性，糖皮质激素是应激期间分泌的肾上腺类固醇。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第17期|p.9457-9462|共6页
作者
S. Brooke; R. Chan; S. Howard;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. EGCG mitigates neurotoxicity mediated by HIV-1 proteins gp120 and Tat in the presence of IFN-gamma: role of JAK/STAT1 signaling and implications for HIV-associated dementia. [J] . Giunta B, Obregon D, Hou H, Brain research . 2006,第1期

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2. Isolation of various forms of sterol beta-d-glucoside from the seed of Cycas circinalis: neurotoxicity and implications for ALS-parkinsonism dementia complex. [J] . Khabazian I, Bains JS, Williams DE, Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 2002,第3期

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3. Differential regulation of Mn-superoxide dismutase in neurons and astroglia by HIV-1 gp120: Implications for HIV-associated dementia. [J] . Saha RN, Pahan K Free Radical Biology and Medicine: The Official Journal of the Oxygen Society . 2007,第12期

机译：HIV-1 gp120对神经元和星形胶质细胞中Mn超氧化物歧化酶的差异调节：对HIV相关痴呆的影响。
4. Neurotoxic oligomeric peptides from the Bri gene cause neuronal loss in familial British and Danish dementias [C] . Brian M.Austen, Omar M.Elagnaf, Gillian L.Gibson International Peptide Symposium;European Peptide Symposium . 2005

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5. Mechanisms of HIV-1 gp120 Neurotoxicity: The Role of Microtubules [D] . Wenzel, Erin Danielle. 2019

机译：HIV-1 GP120神经毒性的机制：微管的作用
6. Endocrine modulation of the neurotoxicity of gp120: Implications for AIDS-related dementia complex [O] . S. Brooke, R. Chan, S. Howard, 1997

机译：gp120的神经毒性的内分泌调节：对艾滋病相关的痴呆症复合体的影响
7. Envelope glycoprotein gp120 of human immunodeficiency virus type 1 alters ion transport in astrocytes: implications for AIDS dementia complex. [O] . Benos, D J, Hahn, B H, Bubien, J K, 1994

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Endocrine modulation of the neurotoxicity of gp120: Implications for AIDS-related dementia complex

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