Characterization of the α_1B-adrenergic receptor gene promoter region and hypoxia regulatory elements in vascular smooth muscle

Andrea D. Eckhart; Nengyu Yang; Xiaohua Xin

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Characterization of the α_1B-adrenergic receptor gene promoter region and hypoxia regulatory elements in vascular smooth muscle

机译：血管平滑肌中α_1B-肾上腺素能受体基因启动子区和缺氧调控元件的表征

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We previously demonstrated that α_1B-adrener- gic receptor (AR) gene transcription, mRNA, and functionally coupled receptors increase during 3/100 O_2 exposure in aorta, but not in vena cava smooth muscle cells (SMC). We report here that α_1BAR mRNA also increases during hypoxia in liver and lung, but not heart and kidney. A single 2.7-kb α_1BAR mRNA was detected in aorta and vena cava during normoxia and hypoxia. The α_1BAR 5' flanking region was sequenced to -2,460 (relative to ATG +1). Transient transfection experiments identify the minimal pro- moter region between -270 and -143 and sequence between -270 and -248 that are required for transcription of the α_1BAR gene in aorta and vena cava SMC during normoxia and hypoxia.

机译：我们先前证明，在主动脉中3/100 O_2暴露期间，α_1B肾上腺素能受体（AR）基因的转录，mRNA和功能性偶联受体会增加，而在腔静脉平滑肌细胞（SMC）中则不会。我们在这里报告说，α_1BARmRNA在肝脏和肺缺氧时也会增加，但在心脏和肾脏中却不会。在常氧和低氧期间，在主动脉和腔静脉中检测到单个2.7-kbα_1BARmRNA。 α_1BAR5'侧翼区域的序列为-2,460（相对于ATG +1）。瞬时转染实验确定了在常氧和低氧期间，主动脉和腔静脉SMC中α_1BAR基因转录所需的最小启动子区域-270和-143之间以及序列-270和-248之间。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第17期|p.9487-9486|共页
作者
Andrea D. Eckhart; Nengyu Yang; Xiaohua Xin;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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6. Characterization of the α1B-adrenergic receptor gene promoter region and hypoxia regulatory elements in vascular smooth muscle [O] . Andrea D. Eckhart, Nengyu Yang, Xiaohua Xin, 1997

机译：血管平滑肌中α1B-肾上腺素能受体基因启动子区和缺氧调控元件的表征
7. Characterization of the 1B-adrenergic receptor gene promoter region and hypoxia regulatory elements in vascular smooth muscle [O] . A. D. Eckhart, N. Yang, X. Xin, 1997

机译：血管平滑肌中1B-肾上腺素能受体基因促进区和缺氧调节元件的表征

Characterization of the α_1B-adrenergic receptor gene promoter region and hypoxia regulatory elements in vascular smooth muscle

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