...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Considerations of transcriptional control mechanisms: Do TFIID-core promoter complexes recapitulate nucleosome-like functions?
【24h】

Considerations of transcriptional control mechanisms: Do TFIID-core promoter complexes recapitulate nucleosome-like functions?

机译：转录控制机制的考虑：TFIID核心启动子复合物能否概括核小体样功能？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The general transcription initiation factor TFIID was originally identified, purified, and characterized with a biochemical assay in which accurate transcription initiation is reconstituted with multiple, chromatographically separable activities. Biochemical analyses have demonstrated that TFIID is a multiprotein complex that directs preinitiation complex assembly on both TATA box-containing and TATA- less promoters, and some TFIID subunits have been shown to be molecular targets for activation domains in DNA-binding regulatory proteins. These findings have most commonly been interpreted to support the view that transcriptional activation by upstream factors is the result of enhanced TFIID recruit- ment to the core promoter.
机译：通用转录起始因子TFIID最初是通过生化测定法鉴定，纯化和表征的，其中准确的转录起始可通过多种可色谱分离的活性进行重构。生化分析表明，TFIID是一种多蛋白复合物，可在含TATA盒的启动子和无TATA的启动子上指导预起始复合物的组装，并且某些TFIID亚基已被证明是DNA结合调节蛋白中激活域的分子靶标。这些发现最通常被解释为支持以下观点：上游因子的转录激活是TFIID向核心启动子募集增强的结果。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号