In vitro repair of oxidative DNA damage by human nucleotide excision repair system: Possible explanation for neurodegeneration in Xeroderma pigmentosum patients

Joyce T. Reardon; Tadayoshi Bessho; Hsiang Chuan Kung

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In vitro repair of oxidative DNA damage by human nucleotide excision repair system: Possible explanation for neurodegeneration in Xeroderma pigmentosum patients

机译：人类核苷酸切除修复系统对氧化性DNA损伤的体外修复：色素干性皮肤病患者神经变性的可能解释

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摘要

Xeroderma pigmentosum (XP) patients fail to remove pyrimidine dimers caused by sunlight and, as a consequence, develop multiple cancers in areas exposed to light. The second most common sign, present in 20-30/100 of XP patients, is a set of neurological abnormalities caused by neuronal death in the central and peripheral nervous systems. Neural tissue is shielded from sunlight-induced DNA damage, so the cause of neurodegeneration in XP patients remains unexplained. In this study, we show that two major oxidative DNA lesions, 8-oxoguanine and thymine glycol, are excised from DNA in vitro by the same enzyme system responsible for removing pyrimidine dimers and other bulky DNA adducts.

机译：色素干燥皮肤病（XP）患者无法去除由阳光引起的嘧啶二聚体，因此，在暴露于光的区域会发展出多种癌症。第二个最常见的体征是20-30 / 100的XP患者，是中枢神经系统和周围神经系统神经元死亡引起的一系列神经系统异常。神经组织不受阳光引起的DNA损伤的保护，因此XP患者神经变性的原因尚无法解释。在这项研究中，我们显示了两个主要的氧化性DNA损伤，即8-氧代鸟嘌呤和胸腺嘧啶二醇，是由负责去除嘧啶二聚体和其他大体积DNA加合物的同一酶系统从体外切除的。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第17期|p.9463-9468|共6页
作者
Joyce T. Reardon; Tadayoshi Bessho; Hsiang Chuan Kung;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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1. Xeroderma Pigmentosum C mutations increase oxidative DNA damages by inhibiting Base Excision Repair System's expression and activity [J] . Fayyad N., Beal D., Rezvani H. R., The Journal of investigative dermatology. . 2019,第9Suppla2期

机译：Xeroderma Pigmentosum C突变通过抑制基础切除修复系统的表达和活性来增加氧化DNA损伤
2. SUMOylation of xeroderma pigmentosum group C protein regulates DNA damage recognition during nucleotide excision repair [J] . Masaki Akita, Yon-Soo Tak, Tsutomu Shimura, Scientific reports. . 2015,第1期

机译：色皮病C组蛋白的SUMO化作用调节核苷酸切除修复过程中的DNA损伤识别
3. Localization of xeroderma pigmentosum group A protein and replication protein A on damaged DNA in nucleotide excision repair. [J] . Krasikova YS, Rechkunova NI, Maltseva EA, Nucleic Acids Research . 2010,第22期

机译：在核苷酸切除修复中，干性色素干细菌A蛋白和复制蛋白A在受损DNA上的定位。
4. Radiosensitivity and expression of nucleotide excision repair genes in peripheral blood mononuclear cells of myelodysplastic syndrome patients [C] . Sadayuki Ban, Ken Kuramoto, Kenji Od, International Symposium of Radiation and Homeostasis . 2002

机译：髓细胞增生综合征患者外周血单核细胞中核苷酸切除修复基因的放射敏感性和表达
5. Effects of base sequence on the removal of DNA damage by nucleotide excision repair mechanisms in vitro. [D] . Liu, Yang. 2010

机译：碱基序列对体外核苷酸切除修复机制去除DNA损伤的影响。
6. In vitro repair of oxidative DNA damage by human nucleotide excision repair system: Possible explanation for neurodegeneration in Xeroderma pigmentosum patients [O] . Joyce T. Reardon, Tadayoshi Bessho, Hsiang Chuan Kung, 1997

机译：人类核苷酸切除修复系统对氧化性DNA损伤的体外修复：色素性干皮病患者神经变性的可能解释
7. In vitro repair of oxidative DNA damage by human nucleotide excision repair system: Possible explanation for neurodegeneration in Xeroderma pigmentosum patients [O] . J. T. Reardon, T. Bessho, H. C. Kung, 1997

机译：人核苷酸切除修复系统的氧化DNA损伤的体外修复：Xeroderma Pigmentosum患者中神经变性的可能解释

In vitro repair of oxidative DNA damage by human nucleotide excision repair system: Possible explanation for neurodegeneration in Xeroderma pigmentosum patients

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