Characterization of the antiproliferative signal mediated by the somatostatin receptor subtype sst5

Pierre Cordelier; Jean-Pierre Esteve; Corinne Bousquet

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Characterization of the antiproliferative signal mediated by the somatostatin receptor subtype sst5

【24h】

Characterization of the antiproliferative signal mediated by the somatostatin receptor subtype sst5

机译：生长抑素受体亚型sst5介导的抗增殖信号的表征

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

We investigated cell proliferation modulated by cholecystokinin (CCK) and somatostatin analogue RC-160 in CHO cells bearing endogenous CCKA receptors and stably transfected by human subtype sst5 somatostatin receptor. CCK stimulated cell proliferation of CHO cells. This effect was suppressed by inhibitor of the soluble guanylate cyclase, LY 83583, the inhibitor of the cGMP dependent kinases, KT 5823, and the inhibitor of mitogen-activated protein (MAP) kinase kinase, PD 98059. CCK treatment induced an increase of intracellular cGMP concentrations, but concomitant addi- tion of LY 83583 virtually suppressed this increase.

机译：我们研究了胆囊收缩素（CCK）和生长抑素类似物RC-160在带有内源CCKA受体并被人类sst5生长抑素亚型稳定转染的CHO细胞中调节的细胞增殖。 CCK刺激CHO细胞的细胞增殖。可溶性鸟苷酸环化酶抑制剂LY 83583，cGMP依赖性激酶抑制剂KT 5823和丝裂原活化蛋白（MAP）激酶激酶PD 98059抑制了这种作用。CCK治疗诱导了细胞内细胞增多。 cGMP浓度，但同时添加LY 83583，实际上抑制了这种增加。

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第17期|p.9343-9348|共6页
作者
Pierre Cordelier; Jean-Pierre Esteve; Corinne Bousquet;
展开▼
作者单位

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
关键词

相似文献

外文文献
中文文献
专利

1. Truncated variants of pig somatostatin receptor subtype 5 (sst5) act as dominant-negative modulators for sst2-mediated signaling [J] . Mario Durae-Prado, Manuel D. Gafaete, Elena Delgado-Niebla, American Journal of Physiology . 2012,第6aPta1期

机译：猪生长抑素受体亚型5（sst5）的截短变体充当sst2介导信号的显性负调节剂
2. Characterization of somatostatin receptors (SSTRs) expression and antiproliferative effect of somatostatin analogues in aggressive thyroid cancers [J] . Carmona Matos Danilea M., Jang Samuel, Hijaz Baraa, Surgery . 2019,第1期

机译：生长抑素受体（SSTR）对生长抑素类似物在侵袭性甲状腺癌中的表达及抗增殖效应的表征
3. Differential Efficacies of Somatostatin Receptor Agonists for G-Protein Activation and Desensitization of Somatostatin Receptor Subtype 4-Mediated Responses [J] . Mia Engstrbm, Juha-Matti Savola, Siegfried Wurster The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2006,第3期

机译：生长抑素受体激动剂对G蛋白激活和促生长素抑制素受体亚型4介导的脱敏的不同功效。
4. Novel Camptothecin Somatostatin Conjugate in Treatment of Tumor Cells Expressing sst2 Receptors [C] . Philip G. Kasprzyk, Ann V. Fiore, Yeelana Shen American Peptide Symposium . 2013

机译：新型Camptothecin Somatostatin缀合物治疗表达SST2受体的肿瘤细胞
5. Somatostatin receptor-mediated negative modulation of HER2 phosphorylation, signaling, and in vitro invasive potential in breast cancer [D] . Vaidya, Kedar S. 2005

机译：生长抑素受体介导的HER2磷酸化，信号转导和体外浸润潜能在乳腺癌中的负调控
6. Characterization of the antiproliferative signal mediated by the somatostatin receptor subtype sst5 [O] . Pierre Cordelier, Jean-Pierre Estève, Corinne Bousquet, 1997

机译：生长抑素受体亚型sst5介导的抗增殖信号的表征
7. Characterization of human recombinant somatostatin sst5 receptors mediating activation of phosphoinositide metabolism [O] . Wilkinson, Graeme F, Feniuk, Wasyl, Humphrey, Patrick P A 1997

机译：介导磷酸肌醇代谢激活的人类重组生长抑素sst5受体的表征
8. Induction of Human Somatostatin Receptor Subtype 2 on Breast Tumors with an Adenoviral Vector for Their Treatment and Detection with a Radiolabeled Peptide [R] . Rogers, B. E. 2002

机译：用腺病毒载体诱导人生长抑素受体亚型2在乳腺肿瘤中用放射性标记肽进行治疗和检测

Characterization of the antiproliferative signal mediated by the somatostatin receptor subtype sst5

摘要

著录项

相似文献

相关主题

期刊订阅