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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Delayed loss of cholesterol from a localized lipoprotein depot in apolipoprotein A-I-deficient mice
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Delayed loss of cholesterol from a localized lipoprotein depot in apolipoprotein A-I-deficient mice

机译：载脂蛋白A-I缺陷小鼠局部脂蛋白仓库中胆固醇的延迟丢失

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摘要

The anti-atherogenic role of high density lipoprotein is well known even though the mechanism has not been established. In this study, we have used a novel model system to test whether removal of lipoprotein cholesterol from a localized depot will be affected by apolipoprotein A-I (apo A-I) deficiency. We compared the egress of cholesterol in- jected in the form of cationized low density lipoprotein into the rectus femoris muscle of apo A-I K-O and control mice. When the injected lipoprotein had been labeled with [3H]choles- terol, the t1/2 of labeled cholesterol loss from the muscle was about 4 days in controls and more than 7 days in apo A-I K-O mice.
机译：即使尚未建立机制，高密度脂蛋白的抗动脉粥样硬化作用也是众所周知的。在这项研究中，我们使用了一种新型的模型系统来测试从局部贮库中去除脂蛋白胆固醇是否会受到载脂蛋白A-I（apo A-I）缺乏症的影响。我们比较了以阳离子化低密度脂蛋白形式注射入载脂蛋白A-I K-O和对照小鼠的股直肌的胆固醇的释放。当注射的脂蛋白已被[3H]胆固醇标记时，在对照中从肌肉中标记的胆固醇损失的t1 / 2大约为4天，而载脂蛋白A-1 K-O小鼠则为7天以上。

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