Autoradiographic characterization of [~3H]-5-HT-moduline binding sites in rodent brain and their relationship to 5-HT_1B receptors

Isabelle Cloez-Tayarani; Ana Cardona; Jean-Claude Rousselle

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Autoradiographic characterization of [~3H]-5-HT-moduline binding sites in rodent brain and their relationship to 5-HT_1B receptors

机译：啮齿动物脑中[〜3H] -5-HT-可调节碱结合位点的放射自显影特征及其与5-HT_1B受体的关系

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5-HT-moduline is an endogenous tetrapep- tide [Leu-Ser-Ala-Leu (LSAL)] that was first isolated from bovine brain tissue. To understand the physiological role of this tetrapeptide, we studied the localization of 5-HT- moduline binding sites in rat and mouse brains. Quantitative data obtained with a gaseous detector of β-particles (β- imager) indicated that [~3H]-5-HT-moduline bound specifi- cally to rat brain sections with high affinity (Kd = 0.77 nM and Bmax = 0.26 dpm/mm~2). Using film autoradiography in par- allel, we found that 5-HT-moduline binding sites were ex- pressed in a variety of rat and mouse brain structures.

机译：5-HT-可卡因是一种内源性四肽[Leu-Ser-Ala-Leu（LSAL）]，首先从牛脑组织中分离出来。为了解该四肽的生理作用，我们研究了大鼠和小鼠脑中5-HT-可调节蛋白结合位点的定位。用气态β-粒子探测器（β-成像仪）获得的定量数据表明，[〜3H] -5-HT-可疑碱以高亲和力特异性结合至大鼠脑部（Kd = 0.77 nM，Bmax = 0.26 dpm / mm〜2）。通过平行使用胶片放射自显影技术，我们发现5-HT-丝氨酸结合位点在各种大鼠和小鼠的大脑结构中均有表达。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第18期|p.9899-9904|共6页
作者
Isabelle Cloez-Tayarani; Ana Cardona; Jean-Claude Rousselle;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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Autoradiographic characterization of [~3H]-5-HT-moduline binding sites in rodent brain and their relationship to 5-HT_1B receptors

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