Neuronal death in the central nervous system demonstrates a non-fibrin substrate for plasmin

Stella E. Tsirka; Thomas H. Bugge; Jay L. Degen

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Neuronal death in the central nervous system demonstrates a non-fibrin substrate for plasmin

机译：中枢神经系统的神经元死亡表明纤溶酶是非纤维蛋白底物

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Mice deficient for plasminogen exhibit a variety of pathologies, all of which examined to date are reversed when the animals are also made fibrin(ogen) defi- cient. These results suggested that the predominant, and perhaps exclusive, physiological role of plasminogen is clear- ance of fibrin. Plasminogen-deficient mice also display resis- tance to excitotoxin-induced neurodegeneration, in contrast with wild-type mice, which are sensitive. Based on the genetic interaction between plasminogen and fibrinogen, we investi- gated whether resistance to neuronal cell death in the plas- minogen-deficient mice is dependent on fibrin(ogen).

机译：缺乏纤溶酶原的小鼠表现出多种病理，当动物也被制成纤维蛋白（原）缺乏时，迄今所检查的所有病理均可逆转。这些结果表明，纤溶酶原的主要（也许是排他的）生理作用是清除纤维蛋白。与敏感的野生型小鼠相比，缺乏纤溶酶原的小鼠还表现出对兴奋性毒素诱导的神经变性的抵抗力。基于纤溶酶原和纤维蛋白原之间的遗传相互作用，我们研究了纤溶酶原缺陷型小鼠对神经元细胞死亡的抗性是否依赖于纤维蛋白原。

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《Proceedings of the National Academy of Sciences of the United States of America》 |1997年第18期|p.9779-9781|共3页
作者
Stella E. Tsirka; Thomas H. Bugge; Jay L. Degen;
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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类自然科学总论;
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6. Neuronal death in the central nervous system demonstrates a non-fibrin substrate for plasmin [O] . Stella E. Tsirka, Thomas H. Bugge, Jay L. Degen, 1997

机译：中枢神经系统的神经元死亡表明血浆纤维蛋白溶酶为非纤维蛋白底物
7. Neuronal death in the central nervous system demonstrates a non-fibrin substrate for plasmin [O] . S. E. Tsirka, T. H. Bugge, J. L. Degen, 1997

机译：中枢神经系统中的神经元死亡证明了纤溶酶的非纤维蛋白基质
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Neuronal death in the central nervous system demonstrates a non-fibrin substrate for plasmin

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